| Gene Symbol |
LGALS9
|
| Entrez Gene |
3965
|
| Alt Symbol |
HUAT, LGALS9A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lectin, galactoside-binding, soluble, 9
|
| Other Description |
ecalectin|gal-9|galectin 9|galectin-9|tumor antigen HOM-HD-21|urate transporter/channel protein
|
| Swissprots |
Q53FQ0 A7VJG6 O14532 O75028 O00182 Q3B8N1 Q9NQ58
|
| Accessions |
BAB83623 BAB83624 BAB83625 CAB93851 EAW51037 EAW51038 EAW51039 EAW51040 EAW51041 EAW51042 EAW51043 EAW51044 EAW51045 O00182 AB003517 BAF76327 AB005894 BAA31542 AB006782 BAA22166 AB008492 BAF76328 AK126017 BAG54277 AK223232 BAD96952 AK296031 BAG58799 AK301624 BAG63109 BC034392 BC105942 AAI05943 BC105944 AAI05945 BC110340 AAI10341 Z49107 CAA88922 XM_006721892 XP_006721955 XM_006721893 XP_006721956 XM_006721894 XP_006721957 XM_006721895 XP_006721958 XM_011524796 XP_011523098 NM_002308 NP_002299 NM_009587 NP_033665 NR_024043
|
| Function |
Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. {ECO:0000269|PubMed:16286920, ECO:0000269|PubMed:18005988, ECO:0000269|PubMed:18977853}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=May also be secreted by a non-classical secretory pathway. {ECO:0000250}.
|
| Tissue Specificity |
Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue.
|