| Gene Symbol |
SLCO4C1
|
| Entrez Gene |
353189
|
| Alt Symbol |
OATP-H, OATP-M1, OATP4C1, OATPX, PRO2176, SLC21A20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier organic anion transporter family, member 4C1
|
| Other Description |
organic anion transporter M1|solute carrier family 21 member 20|solute carrier organic anion transporter family member 4C1
|
| Swissprots |
Q6ZQN7 Q86UG5
|
| Accessions |
EAW49099 EAW49100 Q6ZQN7 AF119865 AAF69619 AF401643 AAQ03086 AK128854 BAC87647 AY273896 AAP33047 BC148351 AAI48352 BC152989 AAI52990 BX647349 BX647577 BX647880 CAH56201 XM_011543370 XP_011541672 XM_011543371 XP_011541673 XM_011543372 XP_011541674 NM_180991 NP_851322
|
| Function |
Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion- transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg. {ECO:0000250|UniProtKB:Q8BGD4,
|
| Subcellular Location |
Basolateral cell membrane {ECO:0000250|UniProtKB:Q71MB6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q71MB6}. Note=Detected at the basolateral membrane of the proximal tubule cell in the kidney. {ECO:0000250|UniProtKB:Q71MB6}.
|
| Tissue Specificity |
Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney. {ECO:0000269|PubMed:14993604}.
|