| Gene Symbol | CD8A |
|---|---|
| Entrez Gene | 925 |
| Alt Symbol | CD8, Leu2, MAL, p32 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD8a molecule |
| Other Description | CD8 antigen, alpha polypeptide (p32)|Leu2 T-lymphocyte antigen|OKT8 T-cell antigen|T cell co-receptor|T-cell antigen Leu2|T-cell surface glycoprotein CD8 alpha chain|T-lymphocyte differentiation antigen T8/Leu-2|T8 T-cell antigen |
| Swissprots | P01732 B4DT80 Q13970 Q4ZG17 D6W5M8 |
| Accessions | AAA59674 AAA79217 AAA79218 AAX88864 EAW99438 EAW99439 EAW99440 EAW99441 P01732 AA668685 AK097942 BAG53555 AK124156 BAC85789 AK300089 BAG61892 AY039664 AAK72403 BC025715 AAH25715 DA075688 DB129686 DQ893323 ABM84249 DQ896638 ABM87637 DQ896639 ABM87638 M12824 AAA61133 M12828 AAB04637 NM_001145873 NP_001139345 NM_001768 NP_001759 NM_171827 NP_741969 NR_027353 |
| Function | Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Top Pathways | Hematopoietic cell lineage, T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Antigen processing and presentation |