Blm

Gene Symbol Blm
Entrez Gene 12144
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description Bloom syndrome, RecQ helicase-like
Other Description Bloom syndrome homolog|Bloom syndrome protein homolog|mBLM|recQ helicase homolog
Swissprots O88198 O88700
Accessions EDL06982 EDL06983 O88700 AB008674 BAA32001 AK137022 AK139975 AK157898 AK164605 BB614580 BB655193 BC157095 AAI57096 Z98263 CAB10933 NM_001042527 NP_001035992 NM_007550 NP_031576
Function Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). {ECO:0000269|PubMed:9840919}.
Subcellular Location Nucleus {ECO:0000250}. Note=Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR- dependent manner (By similarity). {ECO:0000250}.
Tissue Specificity Highly expressed in testis 12-14 days after birth (corresponding to the pachytene phase) and at much lower levels in brain, heart, liver, lung, thymus, kidney and spleen. {ECO:0000269|PubMed:9655940}.
Top Pathways Homologous recombination, Fanconi anemia pathway

BLM CRISPR/Cas9 KO Plasmid (m) - sc-419336 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM HDR Plasmid (m) - sc-419336-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM Double Nickase Plasmid (m) - sc-419336-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM Double Nickase Plasmid (m2) - sc-419336-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM CRISPR Activation Plasmid (m) - sc-419336-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM CRISPR Activation Plasmid (m2) - sc-419336-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM Lentiviral Activation Particles (m) - sc-419336-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM Lentiviral Activation Particles (m2) - sc-419336-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BLM siRNA (m) - sc-29809 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

BLM shRNA Plasmid (m) - sc-29809-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

BLM shRNA (m) Lentiviral Particles - sc-29809-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU064331 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN27639 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27639 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BLM siRNA (Mouse) - CRM0387 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

BLM - MBS8200007 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse BLM (NM_007550.4) - SHH246870 from Creative biogene

Category siRNA
Species Reactivities Mouse

BLM shRNA Plasmid (Mouse) - CHM0387 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
Search more