| Gene Symbol | CENPM |
|---|---|
| Entrez Gene | 79019 |
| Alt Symbol | C22orf18, CENP-M, PANE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | centromere protein M |
| Other Description | interphase centromere complex protein 39|proliferation-associated nuclear element protein 1 |
| Swissprots | Q9NSP4 B1AHQ9 A7LM22 Q6I9W3 |
| Accessions | EAW60474 EAW60475 EAW60476 Q9NSP4 AK123479 BAC85624 AL160131 CAB77147 BC000705 AAH00705 BC007495 AAH07495 BE789455 BE797487 BG476718 BM045658 BQ652721 BQ922403 BU556693 BX332140 BX354019 BX417558 CA414668 CR456399 CAG30285 CR457392 CAG33673 EU035297 ABS84666 HY095078 XM_011530368 XP_011528670 NM_001002876 NP_001002876 NM_001110215 NP_001103685 NM_001304370 NP_001291299 NM_001304371 NP_001291300 NM_001304372 NP_001291301 NM_001304373 NP_001291302 NM_024053 NP_076958 |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. {ECO:0000269|PubMed:16716197}. |
| Subcellular Location | Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}. |
| Tissue Specificity | Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells. |