Gene Symbol | GNLY |
---|---|
Entrez Gene | 10578 |
Alt Symbol | 519, D2S69E, LAG-2, LAG2, NKG5, TLA519 |
Species | Human |
Gene Type | protein-coding |
Description | granulysin |
Other Description | T-cell activation protein 519|T-lymphocyte activation gene 519|lymphocyte-activation gene 2|lymphokine LAG-2 |
Swissprots | P22749 P09325 Q6GU08 |
Accessions | AAA59935 CAA00015 CAA00661 CAY55969 EAW99483 EAW99484 EAW99485 EAW99486 P22749 AA883466 AK296106 BAG58856 AK304728 BAG65491 AK308781 AK310057 AK311012 AK311537 AK311538 AK311657 BC023576 AAH23576 BC063245 BQ015680 CR541859 CAG46657 DA932688 DQ892267 ABM83193 DQ895468 ABM86394 X05044 CAA28715 X54101 CAA38035 XM_005264084 XP_005264141 XM_005264085 XP_005264142 XM_005264087 XP_005264144 XM_011532480 XP_011530782 XM_011532481 XP_011530783 NM_001302758 NP_001289687 NM_006433 NP_006424 NM_012483 NP_036615 |
Function | Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis. |
Subcellular Location | Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation. |
Tissue Specificity | Expressed in natural killer and T-cells. |