| Gene Symbol | oxt |
|---|---|
| Entrez Gene | 38288 |
| Alt Symbol | CG17771, CG17772, CG32300, Dmel\CG32300, OXT, anon-i2, dOXT, dXylT |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | peptide O-xylosyltransferase |
| Other Description | CG32300-PB|Peptide-o-xylosyltransferase|drosophila peptide O-xylosyltransferase|oxt-PB |
| Swissprots | Q24116 Q9W034 Q9W035 Q7KVA1 |
| Accessions | AAF47625 Q7KVA1 AJ430595 CAD23246 AY069660 AAL39805 NM_139448 NP_647705 |
| Function | Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. {ECO:0000269|PubMed:11929872}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin |