| Gene Symbol |
oxt
|
| Entrez Gene |
38288
|
| Alt Symbol |
CG17771, CG17772, CG32300, Dmel\CG32300, OXT, anon-i2, dOXT, dXylT
|
| Species |
Drosophila
|
| Gene Type |
protein-coding
|
| Description |
peptide O-xylosyltransferase
|
| Other Description |
CG32300-PB|Peptide-o-xylosyltransferase|drosophila peptide O-xylosyltransferase|oxt-PB
|
| Swissprots |
Q24116 Q9W034 Q9W035 Q7KVA1
|
| Accessions |
AAF47625 Q7KVA1 AJ430595 CAD23246 AY069660 AAL39805 NM_139448 NP_647705
|
| Function |
Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. {ECO:0000269|PubMed:11929872}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate, Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|