| Gene Symbol | Ccar1 |
|---|---|
| Entrez Gene | 67500 |
| Alt Symbol | 2610511G16Rik, 9430036H15Rik, Carp1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cell division cycle and apoptosis regulator 1 |
| Other Description | CARP-1|cell cycle and apoptosis regulatory protein 1|cell division cycle and apoptosis regulator protein 1 |
| Swissprots | Q9CSR5 Q6AXC9 Q05DK6 Q6PAR2 Q05BR1 Q8CH18 Q8BJY0 Q80XE4 Q8CGG1 Q8BVN2 |
| Accessions | EDL32075 EDL32076 EDL32077 EDL32078 EDL32079 Q8CH18 AF465615 AAO17318 AK012111 BAB28040 AK020457 AK031507 AK077151 BAC36646 AK078424 BAC37267 AK215105 BC010199 AAH10199 BC034174 AAH34174 BC039939 AAH39939 BC051052 AAH51052 BC055954 BC060130 AAH60130 BC079652 AAH79652 DQ696475 XM_006513994 XP_006514057 XM_006513995 XP_006514058 XM_006513996 XP_006514059 XM_006513997 XP_006514060 XM_011243537 XP_011241839 NM_026201 NP_080477 |
| Function | Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm, perinuclear region {ECO:0000250}. |
CARP-1 CRISPR/Cas9 KO Plasmid (m) - sc-426598 from Santa Cruz Biotechnology
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CARP-1 HDR Plasmid (m) - sc-426598-HDR from Santa Cruz Biotechnology
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CARP-1 Double Nickase Plasmid (m) - sc-426598-NIC from Santa Cruz Biotechnology
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CARP-1 Double Nickase Plasmid (m2) - sc-426598-NIC-2 from Santa Cruz Biotechnology
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CARP-1 CRISPR Activation Plasmid (m) - sc-426598-ACT from Santa Cruz Biotechnology
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CARP-1 CRISPR Activation Plasmid (m2) - sc-426598-ACT-2 from Santa Cruz Biotechnology
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CARP-1 Lentiviral Activation Particles (m) - sc-426598-LAC from Santa Cruz Biotechnology
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CARP-1 Lentiviral Activation Particles (m2) - sc-426598-LAC-2 from Santa Cruz Biotechnology
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CARP-1 siRNA (m) - sc-77154 from Santa Cruz Biotechnology
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CARP-1 shRNA Plasmid (m) - sc-77154-SH from Santa Cruz Biotechnology
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CARP-1 shRNA (m) Lentiviral Particles - sc-77154-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU059361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28070 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28070 from Sigma-Aldrich
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CCAR1 siRNA (Mouse) - CRM7209 from Cohesion Biosciences
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CCAR1 - MBS8211505 from MyBioSource
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shRNA set against Mouse CCAR1 (NM_026201.3) - SHH255649 from Creative biogene
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Mouse CCAR1 siRNA - orb286685 from Biorbyt
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CCAR1 shRNA Plasmid (Mouse) - CHM7209 from Cohesion Biosciences
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