| Gene Symbol |
CNOT3
|
| Entrez Gene |
4849
|
| Alt Symbol |
LENG2, NOT3, NOT3H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CCR4-NOT transcription complex, subunit 3
|
| Other Description |
CCR4-NOT transcription complex subunit 3|CCR4-associated factor 3|NOT3 (negative regulator of transcription 3, yeast) homolog|leukocyte receptor cluster member 2
|
| Swissprots |
Q9NZN7 Q9UF76 O75175
|
| Accessions |
EAW72192 EAW72193 EAW72194 O75175 AB014591 BAA31666 AF180474 AAF29828 AF211967 AI660119 AK160386 BAD18729 AK300434 BAH13283 AL133647 CAB63766 BC016474 AAH16474 BM781759 BP390470 BQ439042 BU859614 DB076207 XM_005277076 XP_005277133 XM_005277077 XP_005277134 XM_005277078 XP_005277135 XM_005277079 XP_005277136 XM_005277266 XP_005277323 XM_005277267 XP_005277324 XM_005277268 XP_005277325 XM_005277269 XP_005277326 XM_005278279 XP_005278336 XM_005278280 XP_005278337 XM_005278281 XP_005278338 XM_005278282 XP_005278339 XM_006725771 XP_006725834 XM_006725873 XP_006725936 XM_006726062 XP_006726125 XM_006726162 XP_006726225 XM_006726197 XP_006726260 XM_006726198 XP_006726261 XM_006726199 XP_006726262 XM_006726200 XP_006726263 XM_011526992 XP_011525294 XM_011526993 XP_011525295 XM_011547119 XP_011545421 XM_011547120 XP_011545422 XM_011547530 XP_011545832 XM_011547531 XP_011545833 XM_011547781 XP_011546083 XM_011547782 XP_011546084 XM_011547784 XP_011546086 XM_011547785 XP_011546087 XM_011547786 XP_011546088 XM_011547787 XP_011546089 XM_011547981 XP_011546283 XM_011547982 XP_011546284 XM_011547983 XP_011546285 XM_011547984 XP_011546286 XM_011547985 XP_011546287 XM_011547986 XP_011546288 XM_011548160 XP_011546462 XM_011548161 XP_011546463 XM_011548162 XP_011546464 XM_011548163 XP_011546465 XM_011548164 XP_011546466 XM_011548165 XP_011546467 XM_011548352 XP_011546654 XM_011548353 XP_011546655 XM_011548354 XP_011546656 XM_011548355 XP_011546657 XM_011548356 XP_011546658 XM_011548357 XP_011546659 XM_011548564 XP_011546866 XM_011548565 XP_011546867 XM_011548617 XP_011546919 XM_011548618 XP_011546920 XM_011548619 XP_011546921 XM_011548620 XP_011546922 XM_011548621 XP_011546923 XM_011548622 XP_011546924 XM_011548711 XP_011547013 XM_011548712 XP_011547014 XR_254258 XR_254259 XR_254309 XR_254310 XR_254515 XR_254516 XR_430984 XR_431055 XR_431065 XR_431066 XR_952762 XR_952763 XR_952915 XR_952916 XR_952992 XR_952993 XR_953066 XR_953067 XR_953153 XR_953154 NM_014516 NP_055331
|
| Function |
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of emryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:22342980, ECO:0000269|PubMed:22367759}.
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Cytoplasm, P-body {ECO:0000250}. Note=NANOS2 promotes its localization to P-body. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes. {ECO:0000269|PubMed:10637334}.
|
| Top Pathways |
RNA degradation
|
![Western Blot: CNOT3 Overexpression Lysate (Adult Normal) [NBL1-09318] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CNOT3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2621_CNOT3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09318-img0002.jpg)