| Gene Symbol |
USP36
|
| Entrez Gene |
57602
|
| Alt Symbol |
DUB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 36
|
| Other Description |
deubiquitinating enzyme 1|deubiquitinating enzyme 36|ubiquitin carboxyl-terminal hydrolase 36|ubiquitin specific protease 36|ubiquitin thioesterase 36|ubiquitin thiolesterase 36|ubiquitin-specific-processing protease 36
|
| Swissprots |
Q8NDM8 Q05C98 Q6IQ38 Q9P275 Q9NVC8 Q05DD0
|
| Accessions |
CAC37755 EAW89533 EAW89534 EAW89535 EAW89536 Q9P275 AB040886 BAA95977 AK001671 BAA91825 AK022840 BAG51124 AK022913 BAB14306 AK023077 AK225155 AK225426 AL359624 AL833835 CAD38695 AY169386 AAO34133 BC013890 BC016487 AAH16487 BC027992 AAH27992 BC038983 AAH38983 BC071582 AAH71582 XM_005257542 XP_005257599 XM_005257543 XP_005257600 XM_011525065 XP_011523367 XM_011525066 XP_011523368 XM_011525067 XP_011523369 XM_011525068 XP_011523370 XM_011525069 XP_011523371 XM_011525070 XP_011523372 XM_011525071 XP_011523373 XM_011525072 XP_011523374 XR_934510 XR_934512 NM_025090 NP_079366
|
| Function |
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
|
| Tissue Specificity |
Broadly expressed. {ECO:0000269|PubMed:14715245}.
|
![Western Blot: USP36 Overexpression Lysate (Adult Normal) [NBL1-17659] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP36.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/754_USP36%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17659-img0002.jpg)