| Gene Symbol | GRIN2C |
|---|---|
| Entrez Gene | 2905 |
| Alt Symbol | GluN2C, NMDAR2C, NR2C |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
| Other Description | N-methyl D-aspartate receptor subtype 2C|N-methyl-D-aspartate receptor subunit 2C|glutamate [NMDA] receptor subunit epsilon-3|glutamate receptor ionotropic, NMDA 2C |
| Swissprots | B2RTT1 Q14957 |
| Accessions | EAW89202 EAW89203 EAW89204 Q14957 AB208799 BAD92036 BC031077 AAH31077 BC041128 AAH41128 BC059384 AAH59384 BC140801 AAI40802 BC144586 BM686026 L76224 AAA88096 U77782 AAB71624 XM_006721845 XP_006721908 XM_006721846 XP_006721909 XM_011524686 XP_011522988 XM_011524687 XP_011522989 XM_011524688 XP_011522990 XM_011524689 XP_011522991 XM_011524690 XP_011522992 XM_011524691 XP_011522993 XM_011524692 XP_011522994 NM_000835 NP_000826 NM_001278553 NP_001265482 NR_103735 |
| Function | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas. |
| Top Pathways | Amphetamine addiction, cAMP signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction |