| Gene Symbol |
POU2F1
|
| Entrez Gene |
5451
|
| Alt Symbol |
OCT1, OTF1, oct-1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
POU class 2 homeobox 1
|
| Other Description |
NF-A1|OTF-1|Octamer-binding transcription factor-1|POU domain, class 2, transcription factor 1|oct-1|octamer-binding protein 1|octamer-binding transcription factor 1
|
| Swissprots |
B4E029 J3KP77 Q8NEU9 Q5TBT7 B1AL91 Q6PK46 Q9BPV1 P14859 B1AL93
|
| Accessions |
EAW90786 EAW90787 EAW90788 P14859 AK091438 BAG52361 AK124826 AK302525 BAG63798 AK303201 BAG64291 AK308004 AY113189 AAM77920 BC001664 AAH01664 BC003571 AAH03571 BC007388 AAH07388 BC037864 BC052274 AAH52274 BX954888 DA937884 DC370634 S66901 AAB28879 S66902 X13403 CAA31767 XM_011509653 XP_011507955 XM_011509654 XP_011507956 XM_011509655 XP_011507957 NM_001198783 NP_001185712 NM_001198786 NP_001185715 NM_002697 NP_002688 NR_037163
|
| Function |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes. {ECO:0000250, ECO:0000269|PubMed:1684878}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous. Isoform 2 is lymphocyte-specific.
|
![Western Blot: OCT1 Overexpression Lysate (Adult Normal) [NBL1-14617] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OCT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10022_OCT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14617-img0002.jpg)