| Gene Symbol |
BNIP3
|
| Entrez Gene |
664
|
| Alt Symbol |
NIP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BCL2/adenovirus E1B 19kDa interacting protein 3
|
| Other Description |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
|
| Swissprots |
O14620 Q96GP0 Q12983
|
| Accessions |
AAW62256 CAI45349 EAW49143 Q12983 AF002697 AAC16738 AK130264 AK222626 BAD96346 AK295136 BAG58159 BC009342 BC021989 AAH21989 BC067818 AAH67818 BC080643 AAH80643 BX647339 HQ448726 ADQ33204 HY049371 U15174 AAC00022 NM_004052 NP_004043
|
| Function |
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
|
| Subcellular Location |
Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
|
| Top Pathways |
Legionellosis
|