Gene Symbol | TMEM43 |
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Entrez Gene | 79188 |
Alt Symbol | ARVC5, ARVD5, EDMD7, LUMA |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 43 |
Other Description | - |
Swissprots | Q9H076 Q96F19 Q96A63 Q7L4N5 Q96JX0 Q9BTV4 Q8NC30 |
Accessions | EAW64184 EAW64185 EAW64186 EAW64187 Q9BTV4 AF086408 AK026869 AK027466 BAB55131 AK027757 BAB55348 AK027827 BAB55396 AK027877 BAB55425 AK074073 BAB84899 AK075010 BAC11350 AK225589 AL136916 CAB66850 AM393160 CAL38038 AY358625 AAQ88988 BC003125 AAH03125 BC008054 AAH08054 BC011719 AAH11719 DA259919 XM_011534109 XP_011532411 NM_024334 NP_077310 |
Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000250}. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B- lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). {ECO:0000250}. |
Tissue Specificity | Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis. {ECO:0000269|PubMed:18230648}. |
TMEM43 CRISPR/Cas9 KO Plasmid (h) - sc-402764 from Santa Cruz Biotechnology
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TMEM43 HDR Plasmid (h) - sc-402764-HDR from Santa Cruz Biotechnology
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TMEM43 Double Nickase Plasmid (h) - sc-402764-NIC from Santa Cruz Biotechnology
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TMEM43 Double Nickase Plasmid (h2) - sc-402764-NIC-2 from Santa Cruz Biotechnology
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TMEM43 CRISPR Activation Plasmid (h) - sc-402764-ACT from Santa Cruz Biotechnology
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TMEM43 CRISPR Activation Plasmid (h2) - sc-402764-ACT-2 from Santa Cruz Biotechnology
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TMEM43 Lentiviral Activation Particles (h) - sc-402764-LAC from Santa Cruz Biotechnology
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TMEM43 Lentiviral Activation Particles (h2) - sc-402764-LAC-2 from Santa Cruz Biotechnology
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TMEM43 siRNA (h) - sc-78426 from Santa Cruz Biotechnology
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TMEM43 shRNA Plasmid (h) - sc-78426-SH from Santa Cruz Biotechnology
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TMEM43 shRNA (h) Lentiviral Particles - sc-78426-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU156061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21629 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21629 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10395 from Sigma-Aldrich
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TMEM43 siRNA (Human) - CRJ2355 from Cohesion Biosciences
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TMEM43 - MBS8236742 from MyBioSource
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TMEM43 shRNA Plasmid (Human) - CHJ2355 from Cohesion Biosciences
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TMEM43 miRNA 3'UTR clone - MiUTR3H-12271 from Creative biogene
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