ZNF268
| Gene Symbol | ZNF268 |
|---|---|
| Entrez Gene | 10795 |
| Alt Symbol | HZF3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | zinc finger protein 268 |
| Other Description | zinc finger protein 3|zinc finger protein HZF3 |
| Swissprots | Q96RH4 Q8TDG8 Q14587 Q9BZJ9 |
| Accessions | EAW54786 EAW54787 EAW54788 EAW54789 Q14587 AF141655 AAG39638 AF317549 AAG59817 AF385187 AAK69307 AF432217 AAL99923 AK027712 BAG51369 AW138703 AY583691 BC058548 BC110542 AAI10543 CN255799 DB079580 DQ057356 DQ057357 DQ057358 DQ057359 DQ057360 DQ057361 X78926 CAA55526 NM_001165881 NP_001159353 NM_001165882 NP_001159354 NM_001165883 NP_001159355 NM_001165884 NP_001159356 NM_001165885 NP_001159357 NM_001165886 NP_001159358 NM_001165887 NP_001159359 NM_003415 NP_003406 NM_152943 NP_694422 |
| Function | Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progression. |
| Subcellular Location | Isoform 1: Nucleus {ECO:0000269|PubMed:23665872}. |
| Tissue Specificity | Overexpressed in ovarian cancer tissues compared to normal ovarian tissues. Isoform 1 and isoform 2 are expressed in squamous epithelium tissues. Isoform 2 is overexpressed in squamous cervical cancer (at protein level). Expressed in blood cells. Isoform 1 is expressed in pancreas, lung, skeletal muscle, heart, placenta, liver, kidney and brain. Isoform 2 expressed in chronic lymphocytic leukemia (CLL) and several tumor cell lines. Isoform 3 is expressed in several tumor cells. Isoform 5 is expressed in fetal liver and several tumor cells. Isoform 6 is weakly expressed in brain, lung amd small intestin and in several tumor cells. Isoform 7 is expressed in fetal liver and several tumor cells. {ECO:0000269|PubMed:12200376, ECO:0000269|PubMed:16735226, ECO:0000269|PubMed:16865230, ECO:0000269|PubMed:18949428, ECO:0000269|PubMed:23091055, ECO:0000269|PubMed:23946776}. |
ZNF268 CRISPR/Cas9 KO Plasmid (h) - sc-411514 from Santa Cruz Biotechnology
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ZNF268 HDR Plasmid (h) - sc-411514-HDR from Santa Cruz Biotechnology
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ZNF268 Double Nickase Plasmid (h) - sc-411514-NIC from Santa Cruz Biotechnology
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ZNF268 Double Nickase Plasmid (h2) - sc-411514-NIC-2 from Santa Cruz Biotechnology
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ZNF268 CRISPR Activation Plasmid (h) - sc-411514-ACT from Santa Cruz Biotechnology
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ZNF268 CRISPR Activation Plasmid (h2) - sc-411514-ACT-2 from Santa Cruz Biotechnology
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ZNF268 Lentiviral Activation Particles (h) - sc-411514-LAC from Santa Cruz Biotechnology
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ZNF268 Lentiviral Activation Particles (h2) - sc-411514-LAC-2 from Santa Cruz Biotechnology
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ZNF268 siRNA (h) - sc-96152 from Santa Cruz Biotechnology
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ZNF268 shRNA Plasmid (h) - sc-96152-SH from Santa Cruz Biotechnology
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ZNF268 shRNA (h) Lentiviral Particles - sc-96152-V from Santa Cruz Biotechnology
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ZNF268 RNAi - H00010795-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN23350 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23350 from Sigma-Aldrich
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ZNF268 siRNA (Human) - CRH7356 from Cohesion Biosciences
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ZNF268 RNAi - H00010795-R02 from Novus Biologicals
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ZNF268 - MBS8201294 from MyBioSource
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shRNA set against Human ZNF268 (NM_003415.2) - SHH453472 from Creative biogene
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Human ZNF268 siRNA - orb267858 from Biorbyt
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ZNF268 shRNA Plasmid (Human) - CHH7356 from Cohesion Biosciences
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ZNF268 miRNA 3'UTR clone - MiUTR4H-TG10184 from Creative biogene
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