| Gene Symbol |
Chia1
|
| Entrez Gene |
81600
|
| Alt Symbol |
2200003E03Rik, AMCase, Chia, YNL
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
chitinase, acidic 1
|
| Other Description |
acidic chitinase|acidic mammalian chitinase
|
| Swissprots |
A0T468 Q9D803 Q99PH2 Q3TVE7 Q91XA9 B8K282 Q9JLN1
|
| Accessions |
EDL07527 EDL07528 EDL07529 Q91XA9 AF154571 AAF31644 AF290003 AAG60018 AK007573 AK008633 BAB25795 AK008650 AK008757 AK160173 BAE35672 BC011134 AAH11134 BC034548 AAH34548 DQ349202 ABC86699 EF094027 ABK78778 NM_023186 NP_075675
|
| Function |
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. Presence in saliva and gastric juice suggests a function as a digestive enzyme. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:12133911, ECO:0000269|PubMed:15192232, ECO:0000269|PubMed:19076793}.
|
| Subcellular Location |
Secreted. Cytoplasm. Cytoplasmic granule. Note=Detected in secretory granules of parotid acinar cells and gastric chief cells and secreted from them into saliva and gastric juice, respectively.
|
| Tissue Specificity |
Detected in macrophages and lung epithelial cells. Detected in the acinar cells of parotid gland and von Ebner's gland but not in submandibular and sublingual glands. Detected in gastric chief cells. Also present in parotid glandular saliva and gastric juice (at protein level). Highly expressed in submandibular gland (PubMed:11085997) and stomach. Highly expressed in parotid gland but not in submandibular and sublingual glands (PubMed:12133911). In tongue, expressed only in von Ebner's gland. Expressed at lower levels in lung. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:12133911, ECO:0000269|PubMed:12971947, ECO:0000269|PubMed:15192232, ECO:0000269|PubMed:18824549}.
|
| Top Pathways |
Amino sugar and nucleotide sugar metabolism
|