Gene Symbol | YARS |
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Entrez Gene | 8565 |
Alt Symbol | CMTDIC, TYRRS, YRS, YTS |
Species | Human |
Gene Type | protein-coding |
Description | tyrosyl-tRNA synthetase |
Other Description | tyrosine tRNA ligase 1, cytoplasmic|tyrosine--tRNA ligase, cytoplasmic|tyrosyl--tRNA ligase|tyrosyl-tRNA synthetase, cytoplasmic |
Swissprots | D3DPQ4 B3KWK4 P54577 Q53EN1 O43276 |
Accessions | CBF71274 CBF84232 CBF89282 CBG00408 CBU95132 CBV01176 CBV03421 CBV13928 CBX53875 EAX07506 EAX07507 EAX07508 P54577 AK026535 AK125213 BAG54166 AK126444 AK127182 AK127879 AK223608 BAD97328 BC001933 AAH01933 BC004151 AAH04151 BC016689 AAH16689 BC035242 DQ891666 ABM82592 DQ894853 ABM85779 U40714 AAB39406 U89436 AAB88409 XM_011542347 XP_011540649 XM_011542348 XP_011540650 NM_003680 NP_003671 |
Function | Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16429158}. |
Top Pathways | Aminoacyl-tRNA biosynthesis |
TyrRS CRISPR/Cas9 KO Plasmid (h) - sc-404560 from Santa Cruz Biotechnology
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TyrRS HDR Plasmid (h) - sc-404560-HDR from Santa Cruz Biotechnology
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TyrRS Double Nickase Plasmid (h) - sc-404560-NIC from Santa Cruz Biotechnology
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TyrRS Double Nickase Plasmid (h2) - sc-404560-NIC-2 from Santa Cruz Biotechnology
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TyrRS CRISPR Activation Plasmid (h) - sc-404560-ACT from Santa Cruz Biotechnology
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TyrRS CRISPR Activation Plasmid (h2) - sc-404560-ACT-2 from Santa Cruz Biotechnology
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TyrRS Lentiviral Activation Particles (h) - sc-404560-LAC from Santa Cruz Biotechnology
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TyrRS Lentiviral Activation Particles (h2) - sc-404560-LAC-2 from Santa Cruz Biotechnology
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TyrRS siRNA (h) - sc-37671 from Santa Cruz Biotechnology
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TyrRS shRNA Plasmid (h) - sc-37671-SH from Santa Cruz Biotechnology
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TyrRS shRNA (h) Lentiviral Particles - sc-37671-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22996 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22996 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12297 from Sigma-Aldrich
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YARS siRNA (Human) - CRH5633 from Cohesion Biosciences
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YARS RNAi - H00008565-R01 from Novus Biologicals
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YARS - MBS8229977 from MyBioSource
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shRNA set against Human YARS (NM_003680.3) - SHH448252 from Creative biogene
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shRNA set against Human YARS(NM_003680.3) - SHL139462 from Creative biogene
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YARS shRNA Plasmid (Human) - CHH5633 from Cohesion Biosciences
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YARS miRNA 3'UTR clone - MiUTR1H-11330 from Creative biogene
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