| Gene Symbol | AFAP1L1 |
|---|---|
| Entrez Gene | 134265 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | actin filament associated protein 1-like 1 |
| Other Description | AFAP1-like protein 1|actin filament-associated protein 1-like 1 |
| Swissprots | Q8N8Z5 Q08AN5 Q08AN4 Q8N9Q4 Q8TED9 Q8IW82 |
| Accessions | EAW61787 Q8TED9 AK074185 BAB85011 AK094067 BAC04277 AK095980 BAC04664 BC040723 AAH40723 BC125093 AAI25094 BC125094 AAI25095 BM998635 DA792192 XM_005268373 XP_005268430 XM_011537558 XP_011535860 NM_001146337 NP_001139809 NM_152406 NP_689619 |
| Function | May be involved in podosome and invadosome formation. {ECO:0000269|PubMed:21333378}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21333378}. Cell projection, podosome {ECO:0000269|PubMed:21333378}. Cell projection, invadopodium {ECO:0000269|PubMed:21333378}. Note=In the cytosol, associated with actin stress fibers. |
| Tissue Specificity | Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein level). In the colon, expressed in the mucous membrane and colonic crypts and in the smooth muscle cell layer which provide movement of the colon (at protein level). In the cerebellum, localized around the Purkinje neurons and the granule cells of the granular layer, but not inside cell bodies (at protein level). Outside of the cerebellar cortex, expressed in glial cells (at protein level). Highly expressed away from the cell bodies within the dentate nucleus (at protein level). {ECO:0000269|PubMed:21333378}. |
AFAP-1L1 CRISPR/Cas9 KO Plasmid (h) - sc-407503 from Santa Cruz Biotechnology
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AFAP-1L1 HDR Plasmid (h) - sc-407503-HDR from Santa Cruz Biotechnology
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AFAP-1L1 Double Nickase Plasmid (h) - sc-407503-NIC from Santa Cruz Biotechnology
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AFAP-1L1 Double Nickase Plasmid (h2) - sc-407503-NIC-2 from Santa Cruz Biotechnology
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AFAP-1L1 CRISPR Activation Plasmid (h) - sc-407503-ACT from Santa Cruz Biotechnology
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AFAP-1L1 CRISPR Activation Plasmid (h2) - sc-407503-ACT-2 from Santa Cruz Biotechnology
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AFAP-1L1 Lentiviral Activation Particles (h) - sc-407503-LAC from Santa Cruz Biotechnology
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AFAP-1L1 Lentiviral Activation Particles (h2) - sc-407503-LAC-2 from Santa Cruz Biotechnology
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AFAP-1L1 siRNA (h) - sc-92010 from Santa Cruz Biotechnology
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AFAP-1L1 shRNA Plasmid (h) - sc-92010-SH from Santa Cruz Biotechnology
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AFAP-1L1 shRNA (h) Lentiviral Particles - sc-92010-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU042921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2914 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2914 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10377 from Sigma-Aldrich
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AFAP1L1 siRNA (Human) - CRJ5136 from Cohesion Biosciences
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AFAP1L1 - MBS8205076 from MyBioSource
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Human AFAP1L1 siRNA - orb275637 from Biorbyt
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AFAP1L1 shRNA Plasmid (Human) - CHJ5136 from Cohesion Biosciences
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