Brca1

Gene Symbol Brca1
Entrez Gene 12189
Alt Symbol -
Species Mouse
Gene Type protein-coding
Description breast cancer 1
Other Description breast cancer associated 1|breast cancer type 1 susceptibility protein homolog
Swissprots Q60957 Q60983 A2A4Q4 P48754
Accessions AAA99742 ABY60627 ACK87008 ACM24793 EDL34053 P48754 AB221610 AB221611 AK086173 AK144702 BAE26023 BB662609 BC003248 AAH03248 BC068303 AAH68303 U31625 AAB17114 U32446 AAA96393 U35641 AAB17113 U36475 AAC52323 U68174 AAD00168 XM_006532064 XP_006532127 XM_006532068 XP_006532131 XR_879509 NM_009764 NP_033894
Function E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Contributes to homologous recombi
Subcellular Location Nucleus {ECO:0000250}. Chromosome {ECO:0000269|PubMed:22549958, ECO:0000269|PubMed:23039116}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. {ECO:0000250}.
Tissue Specificity In the embryo, expressed in otic vesicles at day 9.5. At day 10.5, this expression decreases and high levels are found in the neuroectoderm. At days 11-12.5, high levels in differentiating keratinocytes and whisker pad primordia. At days 14-17, expression also observed in kidney epithelial cells. In the adult, highest levels found in spleen, thymus, lymph nodes, epithelial organs, and alveolar and ductal epithelial cells of the mammary gland. Very low levels in brain, kidney, and skin. No expression in heart, liver or lung.
Top Pathways Ubiquitin mediated proteolysis, Fanconi anemia pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer

BRCA1 CRISPR/Cas9 KO Plasmid (m) - sc-419362 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 HDR Plasmid (m) - sc-419362-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 Double Nickase Plasmid (m) - sc-419362-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 Double Nickase Plasmid (m2) - sc-419362-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 CRISPR Activation Plasmid (m) - sc-419362-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 CRISPR Activation Plasmid (m2) - sc-419362-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 Lentiviral Activation Particles (m) - sc-419362-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 Lentiviral Activation Particles (m2) - sc-419362-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

BRCA1 siRNA (m) - sc-29824 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

BRCA1 shRNA Plasmid (m) - sc-29824-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

BRCA1 shRNA (m) Lentiviral Particles - sc-29824-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU047641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN27695 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27695 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

BRCA1 siRNA (Mouse) - CRM0412 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

BRCA1 - MBS8216073 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse BRCA1 (NM_009764.3) - SHH247550 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse BRCA1 siRNA - orb279888 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

BRCA1 shRNA Plasmid (Mouse) - CHM0412 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

BRCA1 miRNA 3'UTR clone - MiUTR1M-02257 from Creative biogene

Species Reactivities Mouse
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