PQBP1

Gene Symbol PQBP1
Entrez Gene 10084
Alt Symbol MRX2, MRX55, MRXS3, MRXS8, NPW38, RENS1, SHS
Species Human
Gene Type protein-coding
Description polyglutamine binding protein 1
Other Description 38 kDa nuclear protein containing a WW domain|polyglutamine tract-binding protein 1|polyglutamine-binding protein 1
Swissprots Q4VY36 Q4VY25 Q4VY27 O60828 Q4VY29 Q4VY34 Q9GZP2 Q4VY26 Q4VY35 Q9GZU4 Q4VY37 Q4VY30 Q9GZZ4 Q4VY38
Accessions BAB16702 BAB16703 BAB16704 BAB16705 CAP12212 EAW50735 EAW50736 EAW50737 EAW50738 O60828 AB016533 BAA76400 AB041833 BAB16706 AB041834 BAB16707 AB041835 BAB16708 AB041836 BAB16709 AJ005893 CAA06750 AJ242829 CAB44309 AJ973593 CAJ00537 AJ973594 CAJ00538 AJ973595 CAJ00539 AJ973596 CAJ00540 AJ973597 CAJ00541 AJ973598 CAJ00542 AJ973599 CAJ00543 AJ973600 CAJ00544 AJ973601 CAJ00545 AJ973602 CAJ00546 AJ973603 CAJ00547 AJ973604 CAJ00551 AJ973605 CAJ00548 AJ973606 CAJ00549 AJ973607 CAJ00550 BC012358 AAH12358 BE385548 BE396796 BI818141 BX362311 BX369697 CD051018 CD365745 CN292761 CN292769 DQ892221 ABM83147 DQ894883 ABM85809 XM_005272571 XP_005272628 XM_005272572 XP_005272629 XM_011543884 XP_011542186 NM_001032381 NP_001027553 NM_001032382 NP_001027554 NM_001032383 NP_001027555 NM_001032384 NP_001027556 NM_001167989 NP_001161461 NM_001167990 NP_001161462 NM_001167992 NP_001161464 NM_005710 NP_005701 NM_144495 NP_652766 NM_001032385 NM_144494
Function Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:20410308, ECO:0000269|PubMed:23512658}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029, ECO:0000269|PubMed:12062018, ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000250}. Note=Colocalizes with SRSF2 in nuclear speckles (By similarity). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. {ECO:0000250}.
Tissue Specificity Widely expressed with high level in heart, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine and peripheral blood leukocytes. {ECO:0000269|PubMed:10198427, ECO:0000269|PubMed:10332029}.
Top Pathways Spliceosome

PQBP-1 (B-9) - sc-374260 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PQBP-1 (B-9): sc-374260. Western blot analysis of PQBP-1 expression in non-transfected: sc-117752 (A) and mouse PQBP-1 transfected: sc-122739 (B) 293T whole cell lysates.

PQBP-1 (N-20) - sc-26052 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PQBP-1 (C-20) - sc-26054 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PQBP-1 (C-20): sc-26054. Western blot analysis of PQBP-1 expression in Sol8 nuclear extract.

PQBP-1 (FL-265) - sc-32910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PQBP-1 (FL-265): sc-32910. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.

Anti-PQBP1 antibody - ab100797 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling PQBP1 with ab100797 at 1/1000 (1µg/mg). Detection: DAB.

Anti-PQBP1 antibody - ab86525 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PQBP1 antibody (ab86525) at 1 µg/ml (in 5% skim milk / PBS buffer) + OVCAR-3 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-PQBP1 antibody - ab77041 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PQBP1 antibody (ab77041) at 1/500 dilution + immunogen at 0.2 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-PQBP1 Antibody (clone 3H7) - LS-C139406 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H7
Detection limit for recombinant GST tagged PQBP1 is 0.03 ng/ml as a capture antibody.

Anti-PQBP1 Antibody (aa58-107) - LS-C30673 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PQBP1 antibody LS-C30673 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-PQBP1 Antibody (aa72-121) - LS-C101382 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
PQBP1 antibody LS-C101382 Western blot of OVCAR-3 cell lysate.

Anti-PQBP1 Antibody (aa215-265) - LS-C289515 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PQBP1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-PQBP1 used at a dilution of 1:200 (1 ug/mg).

Anti-PQBP1 Antibody (aa150-200) - LS-C286140 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse PQBP1 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-PQBP1 used at a dilution of 1:1000 (1 ug/mg).

PQBP1 Antibody - NBP1-47270 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PQBP1 Antibody [NBP1-47270] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PQBP1 antibody NBP1-47270 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. PQBP1 was also immunoprecipitated by rabbit anti-PQBP1 antibody NBP1-47271, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).

PQBP1 Antibody - NBP1-47271 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PQBP1 Antibody [NBP1-47271] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PQBP1 antibody NBP1-47271 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. PQBP1 was also immunoprecipitated by rabbit anti-PQBP1 antibody NBP1-47270, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 10 seconds (B).

PQBP1 Antibody - NBP1-82619 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Antibody - H00010084-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PQBP1 Antibody [H00010084-A01] - PQBP1 polyclonal antibody (A01), Lot # 060707JCS1 Western Blot analysis of PQBP1 expression in MES-SA/Dx5 ( Cat # L021V1 ).

PQBP1 Antibody (1A11) - H00010084-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1A11

PQBP1 Antibody (3H7) - H00010084-M15 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H7
Immunocytochemistry/Immunofluorescence: PQBP1 Antibody (3H7) [H00010084-M15] - Analysis of monoclonal antibody to PQBP1 on HeLa cell. Antibody concentration 10 ug/ml

PQBP1 Polyclonal Antibody - bs-11751R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11751R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11751R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11751R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11751R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, Cy3 Conjugated - bs-11751R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PQBP1 Polyclonal Antibody, Cy5 Conjugated - bs-11751R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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