| Gene Symbol |
MINPP1
|
| Entrez Gene |
9562
|
| Alt Symbol |
HIPER1, MINPP2, MIPP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
multiple inositol-polyphosphate phosphatase 1
|
| Other Description |
2,3-BPG phosphatase|2,3-bisphosphoglycerate 3-phosphatase|inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase|ins(1,3,4,5)P(4) 3-phosphatase|multiple inositol polyphosphate histidine phosphatase, 1|multiple inositol polyphosphate phosphatase 1|multiple inositol polyphosphate phosphatase 2
|
| Swissprots |
Q9UNW1 Q59EJ2 O95172 O95286 Q9UGA3 F5H683
|
| Accessions |
AAD02438 EAW50185 EAW50186 Q9UNW1 AB209819 BAD93056 AF046914 AAD02437 AF084943 AAD09751 AF084944 AAD09752 AK304624 BAG65406 AK309176 AK312937 BAG35779 AL050356 CAB43673 AW243689 AY358938 AAQ89297 BC032504 AAH32504 BU173009 DA295586 HQ447272 ADQ31759 XM_006718078 XP_006718141 XM_011540379 XP_011538681 XR_945884 NM_001178117 NP_001171588 NM_001178118 NP_001171589 NM_004897 NP_004888
|
| Function |
Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). {ECO:0000269|PubMed:18413611}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
|
| Tissue Specificity |
Widely expressed with highest levels in kidney, liver and placenta. {ECO:0000269|PubMed:9923613}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Inositol phosphate metabolism
|