| Gene Symbol | Fgd2 |
|---|---|
| Entrez Gene | 26382 |
| Alt Symbol | Tcd-2, Tcd2, ZFYVE4, tcs-2, tcs2 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | FYVE, RhoGEF and PH domain containing 2 |
| Other Description | FYVE, RhoGEF and PH domain-containing protein 2|Fgd1 family, member 2|Fgd2-like protein|faciogenital dysplasia homolog 2|faciogenital dysplasia protein 2|t-complex distorter 2 |
| Swissprots | Q3U195 O88841 Q8VDH4 Q8BY35 Q2L9D2 Q7TSE3 |
| Accessions | AAP45199 AAP45200 ABY59066 ABY59067 ABY59068 ABY59069 ABY59070 ABY59071 ABY59072 ABY59073 ABY59074 ABY59075 ABY59076 EDL22618 Q8BY35 AF017368 AAC35430 AI451050 AK042260 BAC31206 AK156151 BAE33605 AK179355 BC021845 AAH21845 BY005941 DQ344523 ABC70180 XM_006524299 XP_006524362 XM_006524300 XP_006524363 XM_006524303 XP_006524366 XM_011246472 XP_011244774 XM_011246473 XP_011244775 XR_385330 XR_385331 NM_001159538 NP_001153010 NM_013710 NP_038738 |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. {ECO:0000269|Ref.2}. |
| Subcellular Location | Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}. Early endosome {ECO:0000269|Ref.2}. Early endosome membrane {ECO:0000269|Ref.2}. Cell projection, ruffle membrane {ECO:0000269|Ref.2}. Cytoplasm, cytoskeleton {ECO:0000305|Ref.2}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. |
| Tissue Specificity | Lymph node, spleen, B-lymphocytes and macrophages (at protein level). Expressed at high levels in lymph node, spleen, B-lymphocytes and bone marrow macrophages. Expressed at lower levels in mature bone marrow dendritic cells. In both immature and mature B-cells, expression is down-regulated by prior B-cell receptor signaling. Expression remains high in resting B and memory cells but declines upon differentiation into plasma cells. {ECO:0000269|PubMed:10458911, ECO:0000269|Ref.2}. |