| Gene Symbol |
CHST9
|
| Entrez Gene |
83539
|
| Alt Symbol |
GALNAC4ST-2, GalNAc4ST2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
|
| Other Description |
GalNAc-4-sulfotransferase 2|N-acetylgalactosamine 4-O-sulfotransferase 2|carbohydrate sulfotransferase 9|galNAc-4-O-sulfotransferase 2
|
| Swissprots |
Q9BXH4 Q9BXH3 Q9BZW9 Q7L1S5 Q6UX69
|
| Accessions |
EAX01232 EAX01233 EAX01234 Q7L1S5 AF239821 AAK01862 AF332472 AAK30369 AF332473 AAK30370 AJ707539 AK093349 BAC04141 AK124319 AY358488 AAQ88852 BC025764 AAH25764 BI710997 BM919514 BX119554 DB444451 XM_005258362 XP_005258419 XM_006722555 XP_006722618 XM_011526224 XP_011524526 XM_011526225 XP_011524527 NM_001256316 NP_001243245 NM_031422 NP_113610 NM_001243848
|
| Function |
Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.
|
| Subcellular Location |
Isoform 1: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in trachea. Also expressed in fetal lung, adult pancreas, testis and salivary gland. Expressed at low level in pituitary gland, apex of the heart, adult lung, prostate and mammary gland. Weakly or not expressed in heart, liver and spinal cord. {ECO:0000269|PubMed:11139592, ECO:0000269|PubMed:11445554}.
|
