| Gene Symbol |
MEMO1
|
| Entrez Gene |
51072
|
| Alt Symbol |
C2orf4, CGI-27, MEMO, NS5ATP7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator of cell motility 1
|
| Other Description |
C21orf19-like protein|HCV NS5A-transactivated protein 7|hepatitis C virus NS5A-transactivated protein 7|mediator of ErbB2-driven cell motility 1|protein MEMO1
|
| Swissprots |
Q5R2V8 B4DLS0 D6W575 Q9Y316 Q5R2V9 Q6NSL5
|
| Accessions |
EAX00467 EAX00468 EAX00469 EAX00470 EAX00471 EAX00472 EAX00473 EAX00474 Q9Y316 AB041018 BAD74066 AB041019 BAD74067 AF132961 AAD27736 AF363446 AAL34462 AF529368 AAQ09602 AK057760 AK290753 BAF83442 AK297128 BAG59632 AL161966 BC018733 AAH18733 BC036262 BC070046 AAH70046 BC094681 AAH94681 BG033287 BP248979 BU628425 CD250945 DQ892034 ABM82960 DQ895225 ABM86151 XM_005264352 XP_005264409 XM_011532892 XP_011531194 XM_011532893 XP_011531195 XM_011532894 XP_011531196 XM_011532895 XP_011531197 XM_011532896 XP_011531198 XM_011532897 XP_011531199 XR_244937 NM_001137602 NP_001131074 NM_001301833 NP_001288762 NM_001301852 NP_001288781 NM_015955 NP_057039 NR_126032 NR_126034
|
| Function |
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.
|
