| Gene Symbol |
Adam17
|
| Entrez Gene |
11491
|
| Alt Symbol |
CD156b, Tace
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
a disintegrin and metallopeptidase domain 17
|
| Other Description |
TNF-alpha convertase|TNF-alpha converting enzyme|a disintegrin and metalloproteinase domain 17|disintegrin and metalloproteinase domain-containing protein 17
|
| Swissprots |
O88726 Q9Z0F8 Q9Z0K3 Q9R1U4 Q505A7
|
| Accessions |
AAC62934 EDL34015 EDL34016 EDL34017 EDL34018 Q9Z0F8 AB021709 BAA78578 AJ007365 CAA07480 AK137183 AK137693 BAE23464 AK139471 BAE24023 AK142441 AK144161 BAE25740 AK149288 BAE28792 AK149614 BAE28991 AK165739 BAE38362 AK211820 AK214287 BC026052 BC048792 BC094655 AAH94655 BC114999 AAI15000 BC138416 AAI38417 BC138420 AAI38421 BC145270 AAI45271 BM248808 CA325381 CX220689 U69613 AAD09627 U69614 AAD09628 XM_011243808 XP_011242110 NM_001277266 NP_001264195 NM_001291871 NP_001278800 NM_009615 NP_033745 NR_102380 NR_120376
|
| Function |
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called notch extracellular truncation (NEXT). {ECO:0000250, ECO:0000269|PubMed:10799547, ECO:0000269|PubMed:10882063, ECO:0000269|PubMed:11108241}.
|
| Subcellular Location |
Isoform Long: Cell membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Ubiquitously expressed. Expressed at highest levels in heart, liver, skeletal muscle, kidney and testes. Expressed at lower levels in brain, spleen and lung.
|
| Top Pathways |
Notch signaling pathway, Alzheimer's disease
|