| Gene Symbol |
CD200R1
|
| Entrez Gene |
131450
|
| Alt Symbol |
CD200R, HCRTR2, MOX2R, OX2R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD200 receptor 1
|
| Other Description |
CD200 cell surface glycoprotein receptor|MOX2 receptor|cell surface glycoprotein CD200 receptor 1|cell surface glycoprotein OX2 receptor 1|cell surface glycoprotein receptor CD200
|
| Swissprots |
Q6IS95 Q6UW94 Q8TD52 E9PCM9 Q8TD46 Q8TD44 Q8TD45 B3KWZ9 Q52LJ7 Q6WHB8
|
| Accessions |
CCF77016 CCF77017 CCF77018 CCF77019 EAW79657 EAW79658 EAW79659 EAW79660 EAW79661 Q8TD46 AF283760 AAN61171 AF495380 AAM14622 AF497548 AAM16157 AF497549 AAM16158 AF497550 AAM16159 AK126349 BAG54311 AK293071 BAF85760 AK304426 BAG65254 AY284975 AAQ19772 AY358910 AAQ89269 BC069661 AAH69661 BC069721 AAH69721 BC069743 AAH69743 BC093890 AAH93890 BC143393 AAI43394 HQ447427 ADQ31913 XM_006713492 XP_006713555 NM_138806 NP_620161 NM_138939 NP_620385 NM_138940 NP_620386 NM_170780 NP_740750
|
| Function |
Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. {ECO:0000269|PubMed:12960329}.
|
| Subcellular Location |
Isoform 2: Secreted.
|
| Tissue Specificity |
Expressed in granulocytes, monocytes, most T- cells, neutrophils, basophils and a subset of NK, NKT and B-cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells. {ECO:0000269|PubMed:12960329}.
|
