Ppp1ca

Gene Symbol Ppp1ca
Entrez Gene 24668
Alt Symbol PP1alpha
Species Rat
Gene Type protein-coding
Description protein phosphatase 1, catalytic subunit, alpha isozyme
Other Description PP-1A|Protein phosphatase type 1 alpha, catalytic subunit|protein phosphatase 1, catalytic subunit, alpha isoform|protein phosphatase-1d|serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Swissprots P20653 P08129 P62138 P22802
Accessions EDM12385 EDM12386 P62138 BC070517 AAH70517 D00859 BAA00732 D90163 BAA14194 FQ221064 FQ224860 FQ231613 FQ232496 FQ233040 FQ235125 M58437 AAA41908 NM_031527 NP_113715
Function Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting it to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:7751917}.
Top Pathways Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, cAMP signaling pathway

Rat Ppp1ca cDAN Clone(NM_031527.1) - CDFR012687 from Creative Biomart

Species Rat
Accession NM_031527.1

Rat Ppp1ca ORF Clone(NM_031527.1) - CDCR379720 from Creative Biomart

Species Rat
Accession NM_031527.1

Rat Ppp1ca ORF Clone(NM_031527.1) - CDCR379720 from Creative biogene

Species Rat

Rat Ppp1ca cDNA Clone(NM_031527.1) - CDFR012687 from Creative biogene

Species Rat
Search more