Ppp1ca
| Gene Symbol | Ppp1ca |
|---|---|
| Entrez Gene | 24668 |
| Alt Symbol | PP1alpha |
| Species | Rat |
| Gene Type | protein-coding |
| Description | protein phosphatase 1, catalytic subunit, alpha isozyme |
| Other Description | PP-1A|Protein phosphatase type 1 alpha, catalytic subunit|protein phosphatase 1, catalytic subunit, alpha isoform|protein phosphatase-1d|serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
| Swissprots | P20653 P08129 P62138 P22802 |
| Accessions | EDM12385 EDM12386 P62138 BC070517 AAH70517 D00859 BAA00732 D90163 BAA14194 FQ221064 FQ224860 FQ231613 FQ232496 FQ233040 FQ235125 M58437 AAA41908 NM_031527 NP_113715 |
| Function | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during dev |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting it to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles (By similarity). {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:7751917}. |
| Top Pathways | Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, Inflammatory mediator regulation of TRP channels, cAMP signaling pathway |
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