Gene Symbol | Sycp3 |
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Entrez Gene | 20962 |
Alt Symbol | Cor1, Scp3 |
Species | Mouse |
Gene Type | protein-coding |
Description | synaptonemal complex protein 3 |
Other Description | SCP-3 |
Swissprots | Q3V2A4 Q549A7 P70281 |
Accessions | AAG17538 CAA69720 EDL21484 EDL21485 P70281 AK131949 BAE20894 BC048483 BC089540 BC099552 BC132079 AAI32080 BC138509 AAI38510 BY386732 Y08485 CAA69719 NM_011517 NP_035647 |
Function | Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for axial elements (AE) in meiotic cells and for assembly of the synaptonemal complex. May be important for testis development and male fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2. {ECO:0000269|PubMed:10678170, ECO:0000269|PubMed:22346761}. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000269|PubMed:22346761}. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed. {ECO:0000250}. |
SCP-3 CRISPR/Cas9 KO Plasmid (m) - sc-423232 from Santa Cruz Biotechnology
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SCP-3 HDR Plasmid (m) - sc-423232-HDR from Santa Cruz Biotechnology
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SCP-3 Double Nickase Plasmid (m) - sc-423232-NIC from Santa Cruz Biotechnology
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SCP-3 Double Nickase Plasmid (m2) - sc-423232-NIC-2 from Santa Cruz Biotechnology
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SCP-3 CRISPR Activation Plasmid (m) - sc-423232-ACT from Santa Cruz Biotechnology
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SCP-3 CRISPR Activation Plasmid (m2) - sc-423232-ACT-2 from Santa Cruz Biotechnology
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SCP-3 Lentiviral Activation Particles (m) - sc-423232-LAC from Santa Cruz Biotechnology
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SCP-3 Lentiviral Activation Particles (m2) - sc-423232-LAC-2 from Santa Cruz Biotechnology
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SCP-3 siRNA (m) - sc-37646 from Santa Cruz Biotechnology
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SCP-3 shRNA Plasmid (m) - sc-37646-SH from Santa Cruz Biotechnology
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SCP-3 shRNA (m) Lentiviral Particles - sc-37646-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU041081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42349 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42349 from Sigma-Aldrich
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SYCP3 siRNA (Mouse) - CRM3986 from Cohesion Biosciences
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SYCP3 - MBS8205482 from MyBioSource
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shRNA set against Mouse SYCP3 (NM_011517.2) - SHH421536 from Creative biogene
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SYCP3 shRNA Plasmid (Mouse) - CHM3986 from Cohesion Biosciences
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