| Gene Symbol |
FAT4
|
| Entrez Gene |
79633
|
| Alt Symbol |
CDHF14, CDHR11, FAT-J, FATJ, HKLLS2, NBLA00548, VMLDS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FAT atypical cadherin 4
|
| Other Description |
FAT tumor suppressor homolog 4|cadherin family member 14|cadherin-related family member 11|fat-like cadherin protein FAT-J|protocadherin Fat 4|putative protein product of Nbla00548
|
| Swissprots |
B5MDG4 Q3LIA6 Q8TCK7 Q9H5T6 A8K5Z6 Q6V0I7
|
| Accessions |
EAX05203 Q6V0I7 AB075518 BAE45762 AK026709 BAB15534 AK091292 BAG52326 AK096646 BAG53346 AK291461 BAF84150 AL713715 CAD28510 AY356402 AAR13653 DT932755 DT932756 KJ131481 AHN13819 KJ131482 AHN13820 KJ131483 AHN13821 KJ131484 AHN13822 KJ131485 AHN13823 KJ131486 AHN13824 KJ131487 AHN13825 KJ131488 AHN13826 XM_011532236 XP_011530538 XM_011532237 XP_011530539 NM_001291285 NP_001278214 NM_001291303 NP_001278232 NM_024582 NP_078858
|
| Function |
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In the kidney, localizes to primary cilia. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer. {ECO:0000269|PubMed:15003449, ECO:0000269|PubMed:16865240}.
|