Gene Symbol | Hpse2 |
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Entrez Gene | 545291 |
Alt Symbol | Gm968, Hpa2 |
Species | Mouse |
Gene Type | protein-coding |
Description | heparanase 2 |
Other Description | inactive heparanase-2 |
Swissprots | B2RY83 |
Accessions | B2RY83 AK034730 BC158131 AAI58132 BC158133 AAI58134 BC158136 AAI58137 CN669340 XM_006527214 XP_006527277 XM_011247292 XP_011245594 XM_011247293 XP_011245595 XM_011247294 XP_011245596 XM_011247295 XP_011245597 XM_011247296 XP_011245598 NM_001081257 NP_001074726 |
Function | Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity). {ECO:0000250}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
Top Pathways | Proteoglycans in cancer, Glycosaminoglycan degradation |
Hpse2 CRISPR/Cas9 KO Plasmid (m) - sc-436795 from Santa Cruz Biotechnology
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Hpse2 HDR Plasmid (m) - sc-436795-HDR from Santa Cruz Biotechnology
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Hpse2 Double Nickase Plasmid (m) - sc-436795-NIC from Santa Cruz Biotechnology
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Hpse2 Double Nickase Plasmid (m2) - sc-436795-NIC-2 from Santa Cruz Biotechnology
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Hpse2 CRISPR Activation Plasmid (m) - sc-436795-ACT from Santa Cruz Biotechnology
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Hpse2 CRISPR Activation Plasmid (m2) - sc-436795-ACT-2 from Santa Cruz Biotechnology
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Hpse2 Lentiviral Activation Particles (m) - sc-436795-LAC from Santa Cruz Biotechnology
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Hpse2 Lentiviral Activation Particles (m2) - sc-436795-LAC-2 from Santa Cruz Biotechnology
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Hpse2 siRNA (m) - sc-148692 from Santa Cruz Biotechnology
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Hpse2 shRNA Plasmid (m) - sc-148692-SH from Santa Cruz Biotechnology
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Hpse2 shRNA (m) Lentiviral Particles - sc-148692-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33452 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33452 from Sigma-Aldrich
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HPSE2 siRNA (Mouse) - CRN5142 from Cohesion Biosciences
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HPSE2 - MBS8201406 from MyBioSource
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shRNA set against Mouse HPSE2 (NM_001081257.2) - SHH314737 from Creative biogene
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Mouse HPSE2 siRNA - orb294617 from Biorbyt
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HPSE2 shRNA Plasmid (Mouse) - CHN5142 from Cohesion Biosciences
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