CADM1
| Gene Symbol | CADM1 |
|---|---|
| Entrez Gene | 23705 |
| Alt Symbol | BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell adhesion molecule 1 |
| Other Description | TSLC-1|TSLC1/Nectin-like 2/IGSF4|immunoglobulin superfamily member 4|immunoglobulin superfamily, member 4|immunoglobulin superfamily, member 4D variant 1|immunoglobulin superfamily, member 4D variant 2|nectin-like 2|nectin-like protein 2|spermatogenic immunoglobulin superfamily|synaptic cell adhesion molecule|truncated CADM1 protein|tumor suppressor in lung cancer 1 |
| Swissprots | H1ZZW1 H1ZZW2 H1ZZV9 X5D2C8 F5H0J4 A4FVB5 Q9BY67 Q8N2F4 H0YGA7 Q86WB8 |
| Accessions | ACA06003 ACA06004 BAA75822 CAC39791 CAI58842 CAI72162 CBI85480 EAW67256 EAW67257 EAW67258 EAW67259 EAW67260 Q9BY67 AB094146 BAC66178 AF132811 AAF69029 AK075502 BAC11657 AK172730 AK315245 AL080181 AY309502 AAQ81866 AY358334 AAQ88700 BC035930 BC047021 AAH47021 BC125102 AAI25103 BC125103 AAI25104 BI915307 BM309987 BX641042 CAE46024 BX647110 CA447277 CA777709 CR457157 CAG33438 HE586496 CCD32610 HE586497 CCD32611 HE586498 CCD32612 HE586499 CCD32613 HE586500 CCD32614 HE586501 CCD32615 HE586502 CCD32616 HE586503 CCD32617 KJ534791 AHW56431 KJ534792 AHW56432 KJ534793 AHW56433 KJ534794 AHW56434 KJ534795 AHW56435 KJ534796 AHW56436 KJ534797 AHW56437 XM_005271494 XP_005271551 NM_001098517 NP_001091987 NM_001301043 NP_001287972 NM_001301044 NP_001287973 NM_001301045 NP_001287974 NM_014333 NP_055148 |
| Function | Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the sperma |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:11279526}; Single-pass type I membrane protein {ECO:0000269|PubMed:11279526}. Cell junction, synapse {ECO:0000250}. Note=Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000250|UniProtKB:Q8R5M8, ECO:0000255, ECO:0000269|PubMed:11279526}. |
| Top Pathways | Cell adhesion molecules (CAMs) |
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