RNF11

Gene Symbol	RNF11
Entrez Gene	26994
Alt Symbol	CGI-123, SID1669
Species	Human
Gene Type	protein-coding
Description	ring finger protein 11
Other Description	RING finger protein 11
Swissprots	Q9Y3C5 A8KAI2 Q5T7R8
Accessions	EAX06830 EAX06831 Q9Y3C5 AA224090 AB024703 BAA84683 AF151881 AAD34118 AI817633 AK293047 BAF85736 AK313140 BAG35959 AL049294 BC020964 AAH20964 BC036670 BC047654 AAH47654 DB265274 DB564333 JF432785 ADZ16002 NM_014372 NP_055187
Function	Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome. {ECO:0000269|PubMed:14755250}.
Subcellular Location	Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269|PubMed:16123141}.
Tissue Specificity	Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines. {ECO:000026

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF11 full length protein - ab153277 from Abcam Category Protein Source Wheat germ Species Human

Human RNF11 protein fragment - ab153278 from Abcam Category Protein Source Wheat germ Species Human

RNF11 Antibody Blocking Peptide - LS-E2036 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF11 Antibody Blocking Peptide - LS-E15888 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF11 Antibody Blocking Peptide - LS-E15889 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF11 Protein - H00026994-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF11 Protein - H00026994-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF11-Antibody-Center-Blocking-peptide - BP12908c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF11 - H00026994-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

RNF11 - H00026994-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF11 - H00026994-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF11 fusion protein - Ag10563 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RNF11 fusion protein - Ag11643 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Ring Finger Protein 11 - RNF11-2534H from Creative Biomart Category Protein Source E.coli.

Recombinant Human RNF11, GST-tagged - RNF11-2332H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RING finger protein 11(RNF11) - CSB-YP019816HU CSB-EP019816HU CSB-BP019816HU CSB-MP019816HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF11 Protein - abx163622 from Abbexa Category Protein Species Mouse, Rat

RNF11 - TP308220 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RNF11 Recombinant Protein Antigen - NBP2-13235PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF11 Peptide, Human - M34GP13367H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human RING finger protein 11(RNF11) - AP74013 from Signalway Antibody Category Protein Prices $105.00, $260.00, $454.00, $735.00, $1,240.00, $1,980.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

RING finger protein 11 (RNF11), Recombinant Protein - MBS1387168 from MyBioSource Category Protein Prices $895.00, $895.00, $1,120.00, $1,120.00, $1,315.00, $1,315.00, $1,770.00, $1,770.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RING finger protein 11 (RNF11), Recombinant Protein - MBS9423593 from MyBioSource Category Protein Prices $165.00, $280.00, $435.00, $665.00, $1,080.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source Yeast Species Human

RNF11 Recombinant Protein (Human) (OPCA04414) - OPCA04414 from Aviva Systems Biology Category Protein Species Human

Human RNF11 protein - orb383221 from Biorbyt Category Protein Species Human

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