Gene Symbol | MASP2 |
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Entrez Gene | 10747 |
Alt Symbol | MAP19, MASP-2, MASP1P1, sMAP |
Species | Human |
Gene Type | protein-coding |
Description | mannan-binding lectin serine peptidase 2 |
Other Description | MBL-associated plasma protein of 19 kD|MBL-associated serine protease 2|mannan-binding lectin serine peptidase 1 pseudogene 1|mannan-binding lectin serine protease 1 pseudogene 1|mannan-binding lectin serine protease 2|mannose-binding protein-associated serine protease 2|small MBL-associated protein |
Swissprots | Q5TER0 Q9UMV3 Q96QG4 A8MWJ2 A8K458 Q9UBP3 Q9Y270 O00187 Q9H498 Q9ULC7 Q9UC48 O75754 Q9H499 Q5TEQ5 Q9BZH0 |
Accessions | AAG50274 AAG50275 BAA85658 BAA85659 CAB50732 CAB50733 CAB50734 CAB50735 CAC15568 CAC17138 CAC17139 CAJ58371 CAJ58372 CAJ58410 CAJ58411 CCE53520 CCE53521 CCE67082 CCE67083 CCE67087 CCE67088 CCE67092 CCE67093 CCF12073 CCF12074 CCQ77657 CCQ77658 CCQ77663 CCQ77664 CCQ77668 CCQ77669 CDH61698 CDH61699 EAW71674 O00187 AB008047 BAA78616 AK290823 BAF83512 BC052299 BC067359 BC080556 BC156086 AAI56087 BC156886 AAI56887 DA638135 X98400 CAA67050 Y09926 CAA71059 Y18281 CAB50728 Y18282 CAB50729 Y18283 CAB50730 Y18284 CAB50731 NM_006610 NP_006601 NM_139208 NP_631947 |
Function | Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. {ECO:0000269|PubMed:10946292}. |
Subcellular Location | Secreted. |
Tissue Specificity | Plasma. |
Top Pathways | Complement and coagulation cascades, Staphylococcus aureus infection |
MASP-2 CRISPR/Cas9 KO Plasmid (h) - sc-402549 from Santa Cruz Biotechnology
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MASP-2 HDR Plasmid (h) - sc-402549-HDR from Santa Cruz Biotechnology
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MASP-2 Double Nickase Plasmid (h) - sc-402549-NIC from Santa Cruz Biotechnology
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MASP-2 Double Nickase Plasmid (h2) - sc-402549-NIC-2 from Santa Cruz Biotechnology
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MASP-2 CRISPR Activation Plasmid (h) - sc-402549-ACT from Santa Cruz Biotechnology
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MASP-2 CRISPR Activation Plasmid (h2) - sc-402549-ACT-2 from Santa Cruz Biotechnology
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MASP-2 Lentiviral Activation Particles (h) - sc-402549-LAC from Santa Cruz Biotechnology
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MASP-2 Lentiviral Activation Particles (h2) - sc-402549-LAC-2 from Santa Cruz Biotechnology
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MASP-2 siRNA (h) - sc-42903 from Santa Cruz Biotechnology
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MASP-2 shRNA Plasmid (h) - sc-42903-SH from Santa Cruz Biotechnology
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MASP-2 shRNA (h) Lentiviral Particles - sc-42903-V from Santa Cruz Biotechnology
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MASP2 RNAi - H00010747-R02 from Novus Biologicals
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MISSION® esiRNA - EHU085001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2350 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2350 from Sigma-Aldrich
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MASP2 siRNA (Human) - CRH7324 from Cohesion Biosciences
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MASP2 RNAi - H00010747-R01 from Novus Biologicals
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Human MASP2 siRNA - orb267826 from Biorbyt
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MASP2 shRNA Plasmid (Human) - CHH7324 from Cohesion Biosciences
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MASP2 miRNA 3'UTR clone - MiUTR3H-07375 from Creative biogene
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MASP2 miRNA 3'UTR clone - MiUTR3H-07376 from Creative biogene
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