Gene Symbol | ISCU |
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Entrez Gene | 23479 |
Alt Symbol | 2310020H20Rik, HML, ISU2, NIFU, NIFUN, hnifU |
Species | Human |
Gene Type | protein-coding |
Description | iron-sulfur cluster assembly enzyme |
Other Description | IscU iron-sulfur cluster scaffold homolog|iron-sulfur cluster assembly enzyme ISCU, mitochondrial|nifU-like N-terminal domain-containing protein |
Swissprots | Q9H1K1 Q9H1K2 Q6P713 Q99617 |
Accessions | ACA52543 EAW97818 EAW97819 EAW97820 EAW97821 EAW97822 Q9H1K1 AK000574 AK022758 AK057251 BAG51892 AK293202 BAG56742 AK297862 BAG60191 AY009127 AAG37427 AY009128 AAG37428 BC003522 BC011906 AAH11906 BC061903 AAH61903 BG621612 BG702203 BI597126 BM423850 BM921073 BP378051 BQ002528 BQ020993 BU602914 DB095495 DB493673 DQ896294 ABM87293 EU176420 ABW03871 EU329002 ACA34743 U47101 AAC50885 XM_005268761 XP_005268818 XM_011538100 XP_011536402 XM_011538101 XP_011536403 XR_429087 NM_001301140 NP_001288069 NM_001301141 NP_001288070 NM_014301 NP_055116 NM_213595 NP_998760 |
Function | Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron. {ECO:0000269|PubMed:11060020}. |
Subcellular Location | Isoform 1: Mitochondrion. |
Tissue Specificity | Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta. {ECO:0000269|PubMed:11060020, ECO:0000269|PubMed:8875867}. |
IscU1/2 CRISPR/Cas9 KO Plasmid (h) - sc-402325 from Santa Cruz Biotechnology
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IscU1/2 HDR Plasmid (h) - sc-402325-HDR from Santa Cruz Biotechnology
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IscU1/2 Double Nickase Plasmid (h) - sc-402325-NIC from Santa Cruz Biotechnology
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IscU1/2 Double Nickase Plasmid (h2) - sc-402325-NIC-2 from Santa Cruz Biotechnology
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IscU1/2 CRISPR Activation Plasmid (h) - sc-402325-ACT from Santa Cruz Biotechnology
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IscU1/2 CRISPR Activation Plasmid (h2) - sc-402325-ACT-2 from Santa Cruz Biotechnology
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IscU1/2 Lentiviral Activation Particles (h) - sc-402325-LAC from Santa Cruz Biotechnology
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IscU1/2 Lentiviral Activation Particles (h2) - sc-402325-LAC-2 from Santa Cruz Biotechnology
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IscU1 siRNA (h) - sc-40709 from Santa Cruz Biotechnology
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IscU1 shRNA Plasmid (h) - sc-40709-SH from Santa Cruz Biotechnology
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IscU1 shRNA (h) Lentiviral Particles - sc-40709-V from Santa Cruz Biotechnology
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IscU2 siRNA (h) - sc-40711 from Santa Cruz Biotechnology
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IscU2 shRNA Plasmid (h) - sc-40711-SH from Santa Cruz Biotechnology
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IscU2 shRNA (h) Lentiviral Particles - sc-40711-V from Santa Cruz Biotechnology
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IscU1/2 siRNA (h) - sc-270108 from Santa Cruz Biotechnology
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IscU1/2 shRNA Plasmid (h) - sc-270108-SH from Santa Cruz Biotechnology
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IscU1/2 shRNA (h) Lentiviral Particles - sc-270108-V from Santa Cruz Biotechnology
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ISCU RNAi - H00023479-R01 from Novus Biologicals
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ISCU RNAi - H00023479-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10785 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10785 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03812 from Sigma-Aldrich
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ISCU siRNA (Human) - CRH8297 from Cohesion Biosciences
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ISCU - MBS8200416 from MyBioSource
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shRNA set against Human ISCU (NM_014301.3) - SHH320893 from Creative biogene
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