Gene Symbol |
PTAFR
|
Entrez Gene |
5724
|
Alt Symbol |
PAFR
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
platelet-activating factor receptor
|
Other Description |
PAF-R
|
Swissprots |
A3KMC8 P25105 A8K2H5
|
Accessions |
AAA60214 AAB25755 EAX07711 P25105 AK290240 BAF82929 AK292053 BAF84742 AK313174 BAG35991 AY275466 AAP32298 BC013816 AAH13816 BC063000 AAH63000 BT009801 AAP88803 CD013879 D10202 BAA01050 D31736 BAA06537 DA705644 DA923972 DQ891716 ABM82642 DQ894893 ABM85819 EU832802 ACE87813 GQ129382 ACT64516 L07334 AAA60108 M76674 AAA60002 M80436 AAA60001 S52624 AAB24695 NM_000952 NP_000943 NM_001164721 NP_001158193 NM_001164722 NP_001158194 NM_001164723 NP_001158195
|
Function |
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.
|
Subcellular Location |
Cell membrane {ECO:0000269|PubMed:1374385}; Multi-pass membrane protein {ECO:0000269|PubMed:1374385}.
|
Tissue Specificity |
Expressed in the placenta, lung, left and right heart ventricles, heart atrium, leukocytes and differentiated HL-60 granulocytes. {ECO:0000269|PubMed:1281995, ECO:0000269|PubMed:1656963, ECO:0000269|PubMed:1657923}.
|
Top Pathways |
Calcium signaling pathway, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction
|