FER
| Gene Symbol | FER |
|---|---|
| Entrez Gene | 2241 |
| Alt Symbol | PPP1R74, TYK3, p94-Fer |
| Species | Human |
| Gene Type | protein-coding |
| Description | fer (fps/fes related) tyrosine kinase |
| Other Description | feline encephalitis virus-related kinase FER|fujinami poultry sarcoma/Feline sarcoma-related protein Fer|phosphoprotein NCP94|protein phosphatase 1, regulatory subunit 74|proto-oncogene c-Fer|tyrosine kinase 3|tyrosine-protein kinase Fer |
| Swissprots | H2FLB8 B4DSQ2 P16591 B2RCR4 |
| Accessions | EAW49054 EAW49055 EAW49056 P16591 AK021888 AK092320 AK123847 AK293376 BAG56888 AK296874 BAG59436 AK299855 BAG61714 AK315234 BAG37661 AL707447 BC017060 AAH17060 BC058030 AAH58030 BC141559 AAI41560 BQ009328 BU155168 J03358 AAA61190 JQ412173 AEY69041 XM_011543266 XP_011541568 XM_011543267 XP_011541569 XM_011543268 XP_011541570 XM_011543269 XP_011541571 XM_011543270 XP_011541572 XM_011543271 XP_011541573 XM_011543272 XP_011541574 XM_011543273 XP_011541575 XM_011543274 XP_011541576 XM_011543275 XP_011541577 XM_011543276 XP_011541578 XM_011543277 XP_011541579 XM_011543278 XP_011541580 XR_948244 XR_948245 NM_001308028 NP_001294957 NM_001308031 NP_001294960 NM_001308038 NP_001294967 NM_005246 NP_005237 |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-ne |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell- cell contacts. |
| Tissue Specificity | Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. {ECO:0000269|PubMed:18985748, ECO:0000269|PubMed:2156206, ECO:0000269|PubMed:22223638}. |
| Top Pathways | Adherens junction |
Fer CRISPR/Cas9 KO Plasmid (h) - sc-402734 from Santa Cruz Biotechnology
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Fer HDR Plasmid (h) - sc-402734-HDR from Santa Cruz Biotechnology
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Fer Double Nickase Plasmid (h) - sc-402734-NIC from Santa Cruz Biotechnology
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Fer Double Nickase Plasmid (h2) - sc-402734-NIC-2 from Santa Cruz Biotechnology
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Fer CRISPR Activation Plasmid (h) - sc-402734-ACT from Santa Cruz Biotechnology
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Fer CRISPR Activation Plasmid (h2) - sc-402734-ACT-2 from Santa Cruz Biotechnology
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Fer Lentiviral Activation Particles (h) - sc-402734-LAC from Santa Cruz Biotechnology
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Fer Lentiviral Activation Particles (h2) - sc-402734-LAC-2 from Santa Cruz Biotechnology
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Fer siRNA (h) - sc-39021 from Santa Cruz Biotechnology
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Fer shRNA Plasmid (h) - sc-39021-SH from Santa Cruz Biotechnology
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Fer shRNA (h) Lentiviral Particles - sc-39021-V from Santa Cruz Biotechnology
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Fer RNAi - H00002241-R02 from Novus Biologicals
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MISSION® esiRNA - EHU011991 from Sigma-Aldrich
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MISSION® siRNA - SIHK0759 from Sigma-Aldrich
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MISSION® siRNA - SIHK0761 from Sigma-Aldrich
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MISSION® siRNA - SIHK0760 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2279 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2279 from Sigma-Aldrich
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FER siRNA (Human) - CRH1561 from Cohesion Biosciences
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FER - MBS8224917 from MyBioSource
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shRNA set against Human FER (NM_005246.2) - SHH294045 from Creative biogene
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shRNA set against Human FER(NM_005246.2) - SHH055649 from Creative biogene
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FER shRNA Plasmid (Human) - CHH1561 from Cohesion Biosciences
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FER miRNA 3'UTR clone - MiUTR1H-03611 from Creative biogene
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