| Gene Symbol |
PLA2G10
|
| Entrez Gene |
8399
|
| Alt Symbol |
GXPLA2, GXSPLA2, SPLA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase A2, group X
|
| Other Description |
GX sPLA2|group 10 secretory phospholipase A2|group X secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 10|sPLA2-X
|
| Swissprots |
O15496 Q14DU3 Q6NT23
|
| Accessions |
CCQ43219 EAW85104 O15496 BC069539 AAH69539 BC106731 AAI06732 BC106732 AAI06733 BC111804 AAI11805 CR456885 CAG33166 U95301 AAB64410 XM_011522695 XP_011520997 XM_011522696 XP_011520998 XM_011522697 XP_011520999 XM_011522698 XP_011521000 XM_011546724 XP_011545026 XM_011546725 XP_011545027 XM_011546726 XP_011545028 XM_011546727 XP_011545029 NM_003561 NP_003552
|
| Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.
|
| Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|