Gene Symbol | MTHFD1 |
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Entrez Gene | 4522 |
Alt Symbol | MTHFC, MTHFD |
Species | Human |
Gene Type | protein-coding |
Description | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
Other Description | 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase|C-1-tetrahydrofolate synthase, cytoplasmic|C1-THF synthase|cytoplasmic C-1-tetrahydrofolate synthase |
Swissprots | Q86VC9 Q9BVP5 B2R5Y2 G3V2B8 P11586 |
Accessions | EAW80857 EAW80858 P11586 AK095514 AK302747 BAH13795 AK309266 AK312361 BAG35279 BC001014 AAH01014 BC009806 AAH09806 BC050420 AAH50420 BQ959308 CA446032 DC368835 DQ893634 ABM84560 DQ896853 ABM87852 J04031 AAA59574 NM_005956 NP_005947 |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Ubiquitous. |
Top Pathways | One carbon pool by folate |
MTHFD1 CRISPR/Cas9 KO Plasmid (h) - sc-403353 from Santa Cruz Biotechnology
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MTHFD1 HDR Plasmid (h) - sc-403353-HDR from Santa Cruz Biotechnology
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MTHFD1 Double Nickase Plasmid (h) - sc-403353-NIC from Santa Cruz Biotechnology
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MTHFD1 Double Nickase Plasmid (h2) - sc-403353-NIC-2 from Santa Cruz Biotechnology
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MTHFD1 CRISPR Activation Plasmid (h) - sc-403353-ACT from Santa Cruz Biotechnology
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MTHFD1 CRISPR Activation Plasmid (h2) - sc-403353-ACT-2 from Santa Cruz Biotechnology
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MTHFD1 Lentiviral Activation Particles (h) - sc-403353-LAC from Santa Cruz Biotechnology
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MTHFD1 Lentiviral Activation Particles (h2) - sc-403353-LAC-2 from Santa Cruz Biotechnology
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MTHFD1 siRNA (h) - sc-61082 from Santa Cruz Biotechnology
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MTHFD1 shRNA Plasmid (h) - sc-61082-SH from Santa Cruz Biotechnology
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MTHFD1 shRNA (h) Lentiviral Particles - sc-61082-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU107561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14704 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14704 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01248 from Sigma-Aldrich
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MTHFD1 siRNA (Human) - CRH3001 from Cohesion Biosciences
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shRNA set against Human MTHFD1 (NM_005956.3) - SHH346312 from Creative biogene
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MTHFD1 shRNA Plasmid (Human) - CHH3001 from Cohesion Biosciences
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MTHFD1 miRNA 3'UTR clone - MiUTR3H-01751 from Creative biogene
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