| Gene Symbol |
ENDOV
|
| Entrez Gene |
284131
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
endonuclease V
|
| Other Description |
hEndoV|inosine-specific endoribonuclease
|
| Swissprots |
I3L3S4 Q8NAK0 Q8N8Q3 Q86X99 Q6P2G2
|
| Accessions |
ABF47100 EAW89602 EAW89603 EAW89604 EAW89605 EAW89606 EAW89607 EAW89608 EAW89609 EAW89610 EAW89611 EAW89612 EAW89613 EAW89614 EAW89615 Q8N8Q3 AK056045 AK092539 BAC03912 AK096344 BAC04765 AK096802 AK123689 BAC85677 BC037889 AAH37889 BC045824 AAH45824 BC059781 BC064545 AAH64545 BM714470 BU553848 BX647411 HQ448107 ADQ32588 XM_005257244 XP_005257301 XM_005257246 XP_005257303 XM_006721837 XP_006721900 XM_011524655 XP_011522957 XM_011524656 XP_011522958 XM_011524657 XP_011522959 XM_011524658 XP_011522960 XM_011524659 XP_011522961 XM_011524660 XP_011522962 XM_011524661 XP_011522963 XM_011524662 XP_011522964 XM_011524663 XP_011522965 XM_011524664 XP_011522966 XM_011524665 XP_011522967 XM_011524666 XP_011522968 XM_011524667 XP_011522969 XM_011524668 XP_011522970 XM_011524669 XP_011522971 XM_011524670 XP_011522972 XM_011524671 XP_011522973 XM_011524672 XP_011522974 XM_011524673 XP_011522975 XM_011524674 XP_011522976 XM_011524675 XP_011522977 XM_011524676 XP_011522978 XM_011524677 XP_011522979 XM_011524678 XP_011522980 NM_001164637 NP_001158109 NM_001164638 NP_001158110 NM_173627 NP_775898
|
| Function |
Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures. {ECO:0000269|PubMed:23139746, ECO:0000269|PubMed:23912683, ECO:0000269|PubMed:23912718}.
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus.
|