| Gene Symbol |
HLA-DRB3
|
| Entrez Gene |
3125
|
| Alt Symbol |
HLA-DR3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
major histocompatibility complex, class II, DR beta 3
|
| Other Description |
DR7|HLA class II histocompatibility antigen, DR beta 3 chain|HLA class II histocompatibility antigen, DRB1-7 beta chain|MHC class II HLA-DR beta 3 chain|MHC class II antigen DR beta 3 chain|MHC class II antigen DRB3|human leucocyte antigen DRB3
|
| Swissprots |
O78162 B5AU13 Q9TQ21 Q507L8 A0ZXY9 Q9MYH4 Q9BD18 P79663 O19590 O02875 Q9MYA4 O46701 Q95359 Q6YJU6 Q9TP02 Q5SP44 B5AU14 Q8WLT8 Q95HM8 Q9UIN3 Q2PPD0 B5AU12 Q5STE0 Q70M87 Q9BCP3 Q95IE5 Q7YQ62 Q9TPB5 P01913 Q9UIN5 Q29809 C6H116 Q9MYH3 P79483 Q8WLT7 A7MA46 O46794 Q9TP01 O78049 C6H115 Q29721 Q860I9 Q96H16 Q8SP69 B8YAC6 Q30144
|
| Accessions |
AAA52326 AAA59796 AAA59797 AAB53324 AAB63531 AAB84139 AAB94614 AAC05599 AAC13718 AAC32202 AAC64135 AAC64137 AAD30528 AAD45285 AAD45286 AAD53911 AAF23165 AAF23166 AAF64497 AAF67837 AAK38297 AAK59387 AAK67649 AAK94514 AAL26538 AAL26539 AAL57866 AAL66370 AAM14399 AAP23230 AAP43643 AAY28717 AAY40255 AAY59415 ABA06593 ABA06595 ABC33924 ABC40506 ABG33842 ABR15020 ACF33221 ACF33222 ACF33223 ACL50610 ADV78587 AEV23002 AGL73165 AGW50697 BAO73165 BAO73166 BAO73167 CAA04629 CAA46528 CAA46529 CAA46530 CAA65066 CAA68104 CAA69301 CAA71253 CAA71585 CAA74043 CAB06607 CAB41973 CAB62390 CAB62391 CAB62392 CAC27417 CAC86562 CAD29670 CAD47820 CAD47821 CAD88258 CAD91915 CAE82039 CAE82045 CAE82072 CAL85628 CAO00528 CAZ66766 CAZ66795 CBG98936 CBL42918 CBL80807 CBY44990 CCA30659 CEF25104 EAX03632 P13761 P79483 A06800 CAA00596 AF000448 AAB86437 AF192258 AAF26358 AF192259 AAF26359 AF199236 AAF13065 AK226043 AY138123 AAN15205 BC001023 AAH01023 BC008987 AAH08987 BC106057 AAI06058 HQ447185 ADQ31672 KJ534865 AHW56505 M16941 AAA36282 M17380 AAA59804 M28991 AAA36291 M28992 AAA36285 U66825 AAD43828 U95819 AAD00819 U95820 AAD00820 V00522 CAA23781 NM_022555 NP_072049
|
| Function |
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Lysosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Late endosome membrane {ECO:0000269|PubMed:18305173}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305173}. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
|
| Top Pathways |
Leishmaniasis, Influenza A, HTLV-I infection, Tuberculosis, Herpes simplex infection
|
