Gene Symbol | ERCC6L2 |
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Entrez Gene | 375748 |
Alt Symbol | BMFS2, C9orf102, RAD26L, SR278 |
Species | Human |
Gene Type | protein-coding |
Description | excision repair cross-complementation group 6-like 2 |
Other Description | DNA excision repair protein ERCC-6-like 2|DNA repair and recombination protein RAD26-like|excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2|putative repair and recombination helicase RAD26L|stretch responsive protein 278 |
Swissprots | Q8N9D0 Q8N663 Q5T892 Q5T890 B2RTP8 Q9NPM7 A4D997 Q49AM9 |
Accessions | EAW92635 EAW92636 EAW92637 EAW92639 EAW92640 EAW92641 Q5T890 AK095025 BAC04478 AK307504 AK308131 AK308409 AL133663 AL389952 CAB97530 AL389953 CAB97543 BC022957 AAH22957 BC035183 AAH35183 BC075860 BC140702 AAI40703 BC144261 BG108141 BQ013632 CA425791 CF529128 DB153432 HQ447987 ADQ32469 XM_011518641 XP_011516943 XM_011518642 XP_011516944 XM_011518643 XP_011516945 XM_011518644 XP_011516946 XM_011518645 XP_011516947 XM_011518646 XP_011516948 XM_011518647 XP_011516949 XM_011518648 XP_011516950 XM_011518649 XP_011516951 XM_011518650 XP_011516952 XM_011518651 XP_011516953 XR_929787 XR_929788 XR_929789 NM_001010895 NP_001010895 NM_020207 NP_064592 NM_001034155 |
Function | May be involved in early DNA damage response. {ECO:0000269|PubMed:24507776}. |
Subcellular Location | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mitochondrion. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. |
Tissue Specificity | Expressed in bone marrow (at protein level). {ECO:0000269|PubMed:24507776}. |
Rad26L CRISPR/Cas9 KO Plasmid (h) - sc-407537 from Santa Cruz Biotechnology
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Rad26L HDR Plasmid (h) - sc-407537-HDR from Santa Cruz Biotechnology
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Rad26L Double Nickase Plasmid (h) - sc-407537-NIC from Santa Cruz Biotechnology
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Rad26L Double Nickase Plasmid (h2) - sc-407537-NIC-2 from Santa Cruz Biotechnology
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Rad26L CRISPR Activation Plasmid (h) - sc-407537-ACT from Santa Cruz Biotechnology
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Rad26L CRISPR Activation Plasmid (h2) - sc-407537-ACT-2 from Santa Cruz Biotechnology
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Rad26L Lentiviral Activation Particles (h) - sc-407537-LAC from Santa Cruz Biotechnology
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Rad26L Lentiviral Activation Particles (h2) - sc-407537-LAC-2 from Santa Cruz Biotechnology
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Rad26L siRNA (h) - sc-92601 from Santa Cruz Biotechnology
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Rad26L shRNA Plasmid (h) - sc-92601-SH from Santa Cruz Biotechnology
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Rad26L shRNA (h) Lentiviral Particles - sc-92601-V from Santa Cruz Biotechnology
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RAD26L RNAi - H00375748-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5164 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5164 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03304 from Sigma-Aldrich
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ERCC6L2 siRNA (Human) - CRJ7682 from Cohesion Biosciences
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ERCC6L2 - MBS8217606 from MyBioSource
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shRNA set against Human C9orf102 (NM_001010895.2) - SHH252777 from Creative biogene
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shRNA set against Human LOC375748(NM_001010895.2) - SHH155315 from Creative biogene
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Human ERCC6L2 siRNA - orb278183 from Biorbyt
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ERCC6L2 shRNA Plasmid (Human) - CHJ7682 from Cohesion Biosciences
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ERCC6L2 miRNA 3'UTR clone - MiUTR1H-05791 from Creative biogene
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