| Gene Symbol |
LZTS1
|
| Entrez Gene |
11178
|
| Alt Symbol |
F37, FEZ1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine zipper, putative tumor suppressor 1
|
| Other Description |
F37/Esophageal cancer-related gene-coding leucine-zipper motif|leucine zipper putative tumor suppressor 1
|
| Swissprots |
D3DSQ6 Q9Y250 Q9Y5V9 Q9Y5W1 Q9Y5V7 Q9Y5W0 Q9Y5V8 Q9Y5W2
|
| Accessions |
AAD23834 CBX47464 EAW63752 EAW63753 EAW63754 EAW63755 EAW63756 Q9Y250 AF123652 AAD23833 AF123654 AAD23835 AF123655 AAD23836 AF123656 AAD23837 AF123657 AAD23838 AF123658 AAD23839 AF123659 AAD23840 BC075006 AAH75006 BC075007 AAH75007 EU446940 ABZ92469 XM_005273394 XP_005273451 XM_011544383 XP_011542685 XM_011544384 XP_011542686 XM_011544385 XP_011542687 XM_011544386 XP_011542688 XM_011544387 XP_011542689 NM_021020 NP_066300
|
| Function |
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. {ECO:0000269|PubMed:10097140}.
|