| Gene Symbol |
COBL
|
| Entrez Gene |
23242
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cordon-bleu WH2 repeat protein
|
| Other Description |
cordon-bleu homolog|protein cordon-bleu
|
| Swissprots |
A4D257 Q86XA7 Q8N304 B9EGF8 O75128 Q2T9J3 Q504Y4 A7E2B0 B7ZLW9 Q8TCM1
|
| Accessions |
EAL23896 EAW60962 EAW60963 O75128 AB014533 BAA31608 AK293883 BAG57272 AK308718 AK309254 AL713786 CAD28543 BC029275 AAH29275 BC045771 AAH45771 BC094695 AAH94695 BC111496 AAI11497 BC136441 AAI36442 BC144099 AAI44100 BC150263 AAI50264 CR936689 DA245843 XM_005271750 XP_005271807 XM_005271751 XP_005271808 XM_005271756 XP_005271813 XM_011515234 XP_011513536 XM_011515235 XP_011513537 XM_011515236 XP_011513538 XM_011515237 XP_011513539 XM_011515238 XP_011513540 XM_011515239 XP_011513541 XM_011515240 XP_011513542 XM_011515241 XP_011513543 NM_001287436 NP_001274365 NM_001287438 NP_001274367 NM_015198 NP_056013
|
| Function |
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. {ECO:0000250, ECO:0000269|PubMed:21816349}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity). {ECO:0000250}.
|