| Gene Symbol |
PEG3
|
| Entrez Gene |
5178
|
| Alt Symbol |
PW1, ZKSCAN22, ZNF904, ZSCAN24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
paternally expressed 3
|
| Other Description |
Kruppel-type zinc finger protein|paternally-expressed gene 3 protein|zinc finger and SCAN domain-containing protein 24
|
| Swissprots |
A7E2B8 Q9GZU2 B4DIM4 C9JP50 P78418 Q5H9P9 Q9GZY2 Q7Z7H7 Q8TF75
|
| Accessions |
AAC83176 AAG42324 AAG42325 CCQ43348 EAW72474 EAW72476 EAW72477 EAW72478 Q9GZU2 AB003039 BAB85588 AB006625 BAA22956 AF208967 AAG35739 AF208968 AAG35740 AF208969 AAG35741 AF208970 AAG35742 AI089069 AK295679 BAG58536 AK307476 BC037330 BC052616 AAH52616 BC136268 AAI36269 BC150272 AAI50273 CR933682 CAI45975 U90336 AAB50011 NM_001146184 NP_001139656 NM_001146185 NP_001139657 NM_001146186 NP_001139658 NM_001146187 NP_001139659 NM_006210 NP_006201
|
| Function |
Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. {ECO:0000250, ECO:0000269|PubMed:11260267}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00187}. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. {ECO:0000269|PubMed:11260267, ECO:0000269|PubMed:11331620, ECO:0000269|PubMed:9149948}.
|