| Gene Symbol |
EZH2
|
| Entrez Gene |
2146
|
| Alt Symbol |
ENX-1, ENX1, EZH1, EZH2b, KMT6, KMT6A, WVS, WVS2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
enhancer of zeste 2 polycomb repressive complex 2 subunit
|
| Other Description |
enhancer of zeste homolog 2|histone-lysine N-methyltransferase EZH2|lysine N-methyltransferase 6
|
| Swissprots |
B7Z7L6 B3KS30 Q92857 B2RAQ1 B7Z1D6 Q15755 Q75MG3 Q15910 Q96FI6
|
| Accessions |
AAC50591 AAS02035 AAS02036 AAS07448 AEN79481 CAA03482 CCO13726 EAL24423 EAL24424 EAW80067 EAW80068 EAW80069 EAW80070 Q15910 AB208895 BAD92132 AK092676 BAG52592 AK293239 BAH11472 AK302216 BAH13652 AK303585 BAH13991 AK303637 BAH14002 AK314291 BAG36948 AY519465 AAS09975 BC010858 AAH10858 BG829016 BM974565 BU953788 CN283479 DQ894179 ABM85105 JF327843 AEA07595 U61145 AAC51520 X95653 CAA64955 XM_005249962 XP_005250019 XM_005249963 XP_005250020 XM_005249964 XP_005250021 XM_011515883 XP_011514185 XM_011515884 XP_011514186 XM_011515885 XP_011514187 XM_011515886 XP_011514188 XM_011515887 XP_011514189 XM_011515888 XP_011514190 XM_011515889 XP_011514191 XM_011515890 XP_011514192 XM_011515891 XP_011514193 XM_011515892 XP_011514194 XM_011515893 XP_011514195 XM_011515894 XP_011514196 XM_011515895 XP_011514197 XM_011515896 XP_011514198 XM_011515897 XP_011514199 XM_011515898 XP_011514200 XM_011515899 XP_011514201 XM_011515900 XP_011514202 XM_011515901 XP_011514203 XM_011515902 XP_011514204 NM_001203247 NP_001190176 NM_001203248 NP_001190177 NM_001203249 NP_001190178 NM_004456 NP_004447 NM_152998 NP_694543
|
| Function |
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian gen
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12101246, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:9584199}.
|
| Tissue Specificity |
Expressed in many tissues. Overexpressed in numerous tumor types including carcinomas of the breast, colon, larynx, lymphoma and testis. {ECO:0000269|PubMed:14532106}.
|
| Top Pathways |
MicroRNAs in cancer
|
![Western Blot: KMT6/EZH2 Overexpression Lysate (Adult Normal) [NBL1-10399] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KMT6/EZH2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3916_KMT6-EZH2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10399-img0002.jpg)