BRF1
| Gene Symbol | BRF1 |
|---|---|
| Entrez Gene | 2972 |
| Alt Symbol | BRF, BRF-1, CFDS, GTF3B, HEL-S-76p, TAF3B2, TAF3C, TAFIII90, TF3B90, TFIIIB90, hBRF |
| Species | Human |
| Gene Type | protein-coding |
| Description | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit |
| Other Description | B - related factor 1|BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB|TATA box binding protein (TBP)-associated factor 3C|TATA box binding protein (TBP)-associated factor, RNA polymerase III, GTF3B subunit 2|TBP - associated factor, RNA polymerase III, 90kD|epididymis secretory sperm binding protein Li 76p|general transcription factor IIIB, 90kD subunit|transcription factor IIIB 90 kDa subunit |
| Swissprots | Q3SYD9 Q9HCW7 F5H5Z7 B4DIG5 Q5PR24 Q6IQ02 Q96KX3 B3KU36 B7Z2N3 Q9HCW6 F8WA46 Q92994 Q9HCW8 Q13223 |
| Accessions | EAW81906 EAW81907 EAW81908 EAW81909 EAW81910 EAW81911 EAW81912 Q92994 AJ297406 CAC04512 AJ297407 CAC04513 AJ297408 CAC04514 AK096471 BAG53298 AK124665 BAG54064 AK125024 BAC86024 AK126499 AK294899 BAH11919 AK295579 BAG58477 AL540823 BC016743 AAH16743 BC071637 AAH71637 BC086856 AAH86856 BC103859 AAI03860 BC103860 AAI03861 BC103861 AAI03862 BC133655 AAI33656 BX440529 EU668327 ACF94480 N91109 U28838 AAC50170 U75276 AAB38876 XM_005267561 XP_005267618 XM_005267563 XP_005267620 XM_006720123 XP_006720186 XM_011536672 XP_011534974 XM_011536673 XP_011534975 XM_011536674 XP_011534976 NM_001242786 NP_001229715 NM_001242787 NP_001229716 NM_001242788 NP_001229717 NM_001242789 NP_001229718 NM_001242790 NP_001229719 NM_001519 NP_001510 NM_145685 NP_663718 NM_145696 |
| Function | General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter. |
| Subcellular Location | Nucleus {ECO:0000250}. |
TFIIIB90-1 CRISPR/Cas9 KO Plasmid (h) - sc-405826 from Santa Cruz Biotechnology
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TFIIIB90-1 HDR Plasmid (h) - sc-405826-HDR from Santa Cruz Biotechnology
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TFIIIB90-1 Double Nickase Plasmid (h) - sc-405826-NIC from Santa Cruz Biotechnology
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TFIIIB90-1 Double Nickase Plasmid (h2) - sc-405826-NIC-2 from Santa Cruz Biotechnology
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TFIIIB90-1 CRISPR Activation Plasmid (h) - sc-405826-ACT from Santa Cruz Biotechnology
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TFIIIB90-1 CRISPR Activation Plasmid (h2) - sc-405826-ACT-2 from Santa Cruz Biotechnology
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TFIIIB90-1 Lentiviral Activation Particles (h) - sc-405826-LAC from Santa Cruz Biotechnology
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TFIIIB90-1 Lentiviral Activation Particles (h2) - sc-405826-LAC-2 from Santa Cruz Biotechnology
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TFIIIB90 siRNA (h) - sc-38535 from Santa Cruz Biotechnology
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TFIIIB90-1 shRNA Plasmid (h) - sc-38535-SH from Santa Cruz Biotechnology
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TFIIIB90-1 shRNA (h) Lentiviral Particles - sc-38535-V from Santa Cruz Biotechnology
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BRF1 RNAi - H00002972-R02 from Novus Biologicals
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MISSION® esiRNA - EHU141641 from Sigma-Aldrich
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MISSION® esiRNA - EHU092881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4058 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4058 from Sigma-Aldrich
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BRF1 siRNA (Human) - CRH2013 from Cohesion Biosciences
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BRF1 RNAi - H00002972-R01 from Novus Biologicals
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BRF1 RNAi - H00002972-R03 from Novus Biologicals
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BRF1 - MBS8207593 from MyBioSource
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TFIIIB90-1 CRISPR/Cas9 KO Plasmid (h2) - sc-405826-KO-2 from Santa Cruz Biotechnology
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TFIIIB90-1 HDR Plasmid (h2) - sc-405826-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human BRF1 (NM_001519.3) - SHH247694 from Creative biogene
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shRNA set against Human BRF1(NM_145685.2) - SHG104725 from Creative biogene
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Human BRF1 siRNA - orb262515 from Biorbyt
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