| Gene Symbol |
Ch25h
|
| Entrez Gene |
12642
|
| Alt Symbol |
AI462618, m25OH
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cholesterol 25-hydroxylase
|
| Other Description |
cholesterol 25-monooxygenase
|
| Swissprots |
Q3TUM6 Q8CHQ2 Q9Z0F5
|
| Accessions |
AAC97480 CAR81283 CBX84761 EDL41749 Q9Z0F5 AF059213 AAC97482 AK140360 BAE24352 AK152770 BAE31482 AK160657 BAE35945 BC039919 AAH39919 NM_009890 NP_034020
|
| Function |
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. {ECO:0000269|PubMed:9852097}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:9852097}; Multi-pass membrane protein {ECO:0000269|PubMed:9852097}.
|
| Tissue Specificity |
Widely expressed at low level and at higher level in the lung. Weakly expressed in the heart, lung and kidney. {ECO:0000269|PubMed:9852097}.
|
| Top Pathways |
Primary bile acid biosynthesis
|