TTI1

Gene Symbol TTI1
Entrez Gene 9675
Alt Symbol KIAA0406, smg-10
Species Human
Gene Type protein-coding
Description TELO2 interacting protein 1
Other Description TEL2-interacting protein 1 homolog|TELO2-interacting protein 1 homolog|Tel two interacting protein 1|smg-10 homolog, nonsense mediated mRNA decay factor
Swissprots Q9H4K0 Q96A38 Q5JX67 O43156 Q9BR47 D6W4K3
Accessions EAW76047 EAW76048 EAW76049 EAW76050 O43156 AB007866 BAA23702 AK095451 AK308164 BC013121 AAH13121 BC013755 AAH13755 BC107778 AAI07779 BC131759 AAI31760 BR000854 FAA00688 BU684997 CA419121 DA652320 XM_011529112 XP_011527414 XM_011529113 XP_011527415 XM_011529114 XP_011527416 XM_011529115 XP_011527417 XR_244159 XR_936662 XR_936663 XR_936664 NM_001303457 NP_001290386 NM_014657 NP_055472
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23263282}.
Tissue Specificity Widely expressed.

TTI1 (B-1) - sc-365119 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTI1 (B-1): sc-365119. Western blot analysis of TTI1 expression in HeLa (A) and SK-N-MC (B) whole cell lysates.

TTI1 (F-6) - sc-271851 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTI1 (F-6): sc-271851. Western blot analysis of TTI1 expression in non-transfected 293: sc-110760 (A), human TTI1 transfected 293: sc-113814 (B) and Jurkat (C) whole cell lysates.

TTI1 (L-19) - sc-85604 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal

TTI1 (H-1) - sc-271638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TTI1 (H-1): sc-271638. Western blot analysis of TTI1 expression in non-transfected: sc-110760 (A) and human TTI1 transfected: sc-113814 (B) 293 whole cell lysates.

TTI1 (N-19) - sc-85605 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TTI1 (N-19): sc-85605. Western blot analysis of TTI1 expression in HeLa (A), SK-N-MC (B) and NTERA-2 cl.D1 (C) whole cell lysates.

Anti-TTI1 antibody - ab104077 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TTI1 antibody (ab104077) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-TTI1 Antibody (aa41-69, APC) - LS-C260748 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69, Biotin) - LS-C260749 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69, FITC) - LS-C260750 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69, AP) - LS-C260747 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69, Azide-free, HRP) - LS-C260751 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69, PE) - LS-C260752 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa1-50) - LS-C290125 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa1039-1089) - LS-C290127 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa50-80) - LS-C322341 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTI1 Antibody (aa41-69) - LS-C165382 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of K0406 Antibody in K562 cell line lysates (35 ug/lane). K0406 (arrow) was detected using the purified antibody.

TTI1 Antibody - NBP1-79034 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TTI1 Antibody - NBP1-79035 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: TTI1 Antibody [NBP1-79035] - Whole cell lysate from HeLa (1 mg for IP, 20% of IP loaded) cells. Antibodies: Affinity purified rabbit anti-TTI1 antibody used for IP at 6 mcg/mg lysate. TTI1 was also immunoprecipitated by rabbit anti-TTI1 antibody NBP1-79034 which recognizes an upstream epitope.

Rabbit Anti-TTI1 Polyclonal Antibody - bs-6885R from Bioss

Host Rabbit
Clonality Polyclonal

ANTI-K0406 (N-TERM) antibody produced in rabbit - SAB1302645 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-K0406 (N-term): <B>Cat. No. SAB1302645</B>: Western blot analysis of K0406 Antibody (N-term) in K562 cell line lysates (35 μg/lane).

K0406 Antibody - N-terminal region (OAAB02389) - OAAB02389 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

K0406-Antibody-N-term - AP4976a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of K0406 Antibody (N-term) (Cat. #AP4976a) in K562 cell line lysates (35ug/lane). K0406 (arrow) was detected using the purified Pab.

Anti -K0406, NT (TTI1, KIAA0406, SMG10, TELO2-interacting protein 1 homolog, ProteinSMG10) - 037238 from USBiological Life Science

Host Rabbit
Clonality Polyclonal
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