PECAM1

Gene Symbol PECAM1
Entrez Gene 5175
Alt Symbol CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM
Species Human
Gene Type protein-coding
Description platelet/endothelial cell adhesion molecule 1
Other Description CD31 antigen|platelet endothelial cell adhesion molecule
Swissprots Q8TBH1 Q9NQS9 Q96RF5 Q9NQT2 Q9NPG9 P16284 A8K3S7 Q9NQT0 Q6LDA9 Q96RF6 D3DU31 Q9NQT1 Q9NP65 Q9NPB7
Accessions AAA60057 EAW94207 EAW94208 P16284 AF281287 AAF91446 AF281288 AAF91447 AF281289 AAF91448 AF281290 AAF91449 AF281291 AAF91450 AF281292 AAF91451 AF281293 AAF91452 AF281294 AAF91453 AF281295 AAF91454 AF281296 AAF91455 AF281297 AAF91456 AF281298 AAF91457 AF281299 AAF91458 AF281300 AAF91459 AF281301 AAF91460 AF393676 AAK84009 AF393677 AAK84010 AF393678 AAK84011 AK091419 AK290692 BAF83381 AK303959 BAH14084 AK304166 BAH14122 BC022512 AAH22512 BC051822 AAH51822 BC062608 BG272085 DQ893644 ABM84570 JQ287500 AFA36630 M28526 AAA36429 M37780 AAA36186 S66450 AAB28645 X96849 XM_005276880 XP_005276937 XM_005276881 XP_005276938 XM_005276882 XP_005276939 XM_005276883 XP_005276940 XM_011524889 XP_011523191 XM_011524890 XP_011523192 NM_000442 NP_000433
Function Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the ea
Subcellular Location Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.
Tissue Specificity Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). {ECO:0000269|PubMed:12433657, ECO:0000269|PubMed:19342684}.
Top Pathways Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria

CD31 (PECAM-1) (158-2B3) Mouse mAb - 3568 from Cell Signaling Technology

Prices $239.00
Sizes 400 µl (100 tests)
Host Mouse
Clonality Monoclonal
Clone 158-2B3
Flow cytometric analysis of whole blood using CD31 (158-2B3) Mouse mAb.

CD31 (PECAM-1) (89C2) Mouse mAb - 3528 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 89C2
Western blot analysis of extracts from HUVEC cells using CD31 (PECAM-1) (89C2) Mouse mAb.

PECAM-1 (H-3) - sc-376764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (H-3): sc-376764. Western blot analysis of PECAM-1 expression in Jurkat whole cell lysate.

PECAM-1 (E-4) - sc-365804 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (E-4): sc-365804. Western blot analysis of PECAM-1 expression in Jurkat whole cell lysate.

PECAM-1 (M-20) - sc-1506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PECAM-1 (M-20): sc-1506. Western blot analysis of PECAM-1 expression in Jurkat (A), CTLL-2 (B), WEHI-3 (C) whole cell lysates and human platelet extract (D).

PECAM-1 (M-185) - sc-28188 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PECAM-1 (M-185): sc-28188. Western blot analysis of PECAM-1 expression in Jurkat whole cell lysate.

PECAM-1 (C-20) - sc-1505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PECAM-1 (C-20)-R: sc-1505-R. Western blot analysis of PECAM-1 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.

PECAM-1 (E-8) - sc-133091 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (E-8): sc-133091. Western blot analysis of PECAM-1 expression in Jurkat (A), human PBL (B) and THP-1 (C) whole cell lysates.

PECAM-1 (H-300) - sc-8306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PECAM-1 (H-300): sc-8306. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing cytoplasmic staining.

PECAM-1 (P2B1) - sc-20071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (P2B1) FITC: sc-20071 FITC. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

PECAM-1 (V-16) - sc-31045 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PECAM-1 (10G9) - sc-13537 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (10G9) FITC: sc-13537 FITC. FCM analysis of THP-1 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

PECAM-1 (JC70) - sc-53411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (JC70): sc-53411. Indirect FCM analysis of human peripheral blood leukocytes stained with PECAM-1 (JC70), followed by PE-conjugated goat anti-mouse IgG<sub>1</sub>: sc-3764. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

PECAM-1 (2F7B2) - sc-81158 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (2F7B2): sc-81158. Western blot analysis of PECAM-1 expression in human platelet extract (A) and Jurkat whole cell lysate (B).

PECAM-1 (158-2B3) - sc-65260 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (158-2B3): sc-65260. Western blot analysis of PECAM-1 expression in human PBL whole cell lysate.

PECAM-1 (HC1/6) - sc-59938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (HC1/6): sc-59938. Western blot analysis of PECAM-1 expression in PMA treated U-937 (A), human platelet extract (B), Jurkat (C) and AML-193 (D) whole cell lysates.

PECAM-1 (0.N.100) - sc-71872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PECAM-1 (0.N.100): sc-71872. Western blot analysis of PECAM-1 expression in Jurkat whole cell lysate.

PECAM-1 (EN4) - sc-59169 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-CD31 (phospho Y713) antibody - ab62169 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD31 (phospho Y713) antibody (ab62169) at 1/500 dilutionLane 1 : HepG2 cellsLane 2 : HepG2 cells with blocked with the phospho peptide

Anti-CD31 (phospho Y713) antibody [EPR8079(2)] - C-terminal - ab180175 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8079(2)
All lanes : Anti-CD31 (phospho Y713) antibody [EPR8079(2)] - C-terminal (ab180175) at 1/1000 dilutionLane 1 : Non-treated Jurkat cell lysateLane 2 : Pervanadate-treated Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-CD31 antibody - ab28364 from Abcam

Prices $400.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Anti-CD31 antibody (ab28364) at 1/50 dilution staining mouse tissue sections by Immunohistochemistry (Formalin-fixed paraffin-embedded sections). Folowing heat mediated antigen retrieval the tissue was formaldehyde fixed and blocked with serum. The tissue was incubated with the primary antibody for 20 minutes. A biotinylated goat anti-rabbit antibody was used as the secondary. The endothelium of vessels of any tissues are positive.See Abreview

Anti-CD31 antibody - ab32457 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD31 antibody (ab32457) at 1 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 2 : HUVEC (Human Umbilical Vein Endothelial Cell) Whole Cell LysateLane 3 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutionPerformed under reducing conditions.

Anti-CD31 antibody - ab196808 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue, labeling CD31 with ab196808 at 1/50 dilution. The image on the right is treated with synthesized peptide.

Anti-CD31 antibody - ab83959 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD31 antibody (ab83959) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell LysateLane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD31 antibody - ab154633 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Lung cancer Macrophage endothelial cell tissue, labeling CD31 using ab154633 at 1/250 dilution.
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